P1459 - The Statewide Burden of Pancreatitis in the United States Between 1990-2019: Results from the Global Burden of Disease Study 2019

Mihir Prakash Shah, MD¹, Bashar Attar, MD², Sneh Patel, MBBS³, Jay Gajjar, MBBS⁴, Sahithi Rao Mallyala, MD⁵, Avinash Chirumamilla, MBBS⁶, Deepti Raj, MBBS⁷, Muhammad Bilal Ibrahim, MD¹, Bhanu Siva Mohan Pinnam, MD¹, Chun-Wei Pan, MD¹, Sania Saleem, MD¹, Pius Ehiremen Ojemolon, MD², Daksh Ahluwalia, MD¹, Hardik Dineshbhai Desai, MBBS^8
1John H. Stroger, Jr. Hospital of Cook County, Chicago, IL; ²Cook County Health, Chicago, IL; ³GMERS Medical College Gandhinagar, Chicago, IL; ⁴Smt. NHL Municipal Medical College, Chicago, IL; ⁵Dr. NTR University of Health Sciences, Chicago, IL; ⁶Yenepoya Medical College Mangalore, Chicago, IL; ⁷K. S. Hegde Medical Academy, Mangalore, Chicago, IL; ⁸Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India

Introduction: Pancreatitis represents a significant health burden in the United States (US). This study provides an overview of the current understanding of the burden of pancreatitis across the US.

Methods: Data from the Global Burden of Disease Study 2019 were employed to examine the prevalence, incidence, deaths, and disability-adjusted life years (DALYs) due to pancreatitis in the US by age group, year, and sex. Furthermore, we analyzed the DALYs specifically attributed to alcohol as a causative factor for pancreatitis. The findings were presented in terms of 'total counts' and 'age-standardized rates per 100,000 person-years', providing valuable insights into the burden of pancreatitis in the US.

Results: From 1990-2019, the total prevalent cases of pancreatitis in the US increased from 172,508 (95% uncertainty interval [95%UI]:150,335-194,737) to 264,954 (95%UI:242,040-287,145). During the same period, DALYs associated with pancreatitis rose from 92,110 (95%UI:85,404-100,957) to 133,259(95%UI: 123,425-147,833). Notably, Nevada witnessed the highest annual percentage change (APC) increase in the total number of incidences (167%), followed by Arizona (98%), Utah (72%), and Texas (63%). Conversely, Louisiana, Massachusetts, Pennsylvania, Rhode Island, and the District of Columbia observed a decrease in APC incidence from 1990-2019. When considering total death counts, Nevada experienced the highest APC (222%), trailed by Alaska (158%), and Arizona (145%). The District of Columbia was the only area with decreased death counts during the same period. The highest age-standardized DALYs rate (ASDALR) was observed in the District of Columbia (50.30,95%UI:36.73-63.58), and the highest age-standardized mortality rate (ASMR) was found in the same region (1.52,95%UI:1.11-1.92). West Virginia had the highest ASIR (66.18,95%UI:60.36-72.90) in 2019. In terms of gender differences, males reported higher APC in total incidence (33% vs.18%), deaths (63% vs.58%), and DALYs (46% vs.43%) from 1990-2019. Additionally, the older age group (95+ age group) showed an increased APC in deaths, with a rise of 267% from 1990-2019.

Discussion: While the ASIR, ASMR, and ASDALR have shown a decrease across the US from 1990-2019, the overall burden of pancreatitis remains significant. Moreover, there exist substantial differences in the burden of pancreatitis among different regions, highlighting the need for geographically targeted considerations in designing future interventions.



Disclosures:


Mihir Prakash Shah, MD¹, Bashar Attar, MD², Sneh Patel, MBBS³, Jay Gajjar, MBBS⁴, Sahithi Rao Mallyala, MD⁵, Avinash Chirumamilla, MBBS⁶, Deepti Raj, MBBS⁷, Muhammad Bilal Ibrahim, MD¹, Bhanu Siva Mohan Pinnam, MD¹, Chun-Wei Pan, MD¹, Sania Saleem, MD¹, Pius Ehiremen Ojemolon, MD², Daksh Ahluwalia, MD¹, Hardik Dineshbhai Desai, MBBS⁸. P1459 - The Statewide Burden of Pancreatitis in the United States Between 1990-2019: Results from the Global Burden of Disease Study 2019, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.