P1694 - Metastatic Melanoma With GI Involvement

Mauricio Jones, DO¹, Mark Shell, DO¹, Richard Erikson, MD^2
1Baylor Scott & White, Temple, TX; ²Baylor Scott & White Hospital, Temple, TX

Introduction: We present a case of a 63-year-old female with metastatic melanoma found in the sigmoid colon during colonoscopy confirmed after biopsy. Although metastatic melanoma can affect almost every part of the body including the liver, lungs, and CNS, GI tract involvement is rare. This case report will demonstrate a rare case of metastatic melanoma with GI tract involvement.

Case Description/Methods: This case report presents a 63-year-old female who initially presented with two cutaneous melanomas in the upper back and suprapubic areas with negative margins and negative sentinel node biopsies after being excised. Patient was referred to for further workup. PET scan performed showed areas of increased uptake in the gallbladder and sigmoid colon. She underwent cholecystectomy for malignant neoplasm favoring metastatic melanoma and was referred to GI for colonoscopy. Colonoscopy findings (images provided) and biopsies confirmed metastatic melanoma.

Discussion: In the US, roughly 95,000 are diagnosed with melanoma and almost 10% (8,000) people die from melanoma yearly. Melanoma can metastasize to almost any part of the body. Pulmonary involvement from metastatic melanoma is the most common cause of death due to respiratory failure. CNS involvement is the second most common metastatic melanoma-related deaths due to significant risk of hemorrhage. Most common visceral organ affected by melanoma is the liver. GI tract involvement is rare and is associated with a poor prognosis. However, one study claims that it is likely underdiagnosed and found colonic involvement in 22-28% of patients with metastatic melanoma at autopsy.



Disclosures:


Mauricio Jones, DO¹, Mark Shell, DO¹, Richard Erikson, MD². P1694 - Metastatic Melanoma With GI Involvement, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.