Momin Samad, MD1, Syed-Mohammed Jafri, MD2 1Henry Ford Hospital, Rochester Hills, MI; 2Henry Ford Health System, Detroit, MI
Introduction: The study aims to analyze the infectious complications and mortality associated with small intestine transplant (SIT) patients on immunosuppressive therapy.
Methods: A retrospective cohort study was conducted at a single, urban quaternary care center in midwestern United States and consisted of 27 patients receiving immunotherapy following SIT from 2012-2022. Data points that were collected included age at transplant, sex, and causal organism of infection. Patients were categorized into three groups based on onset of infection (within six/6-12 months/beyond 12 months of transplant). Primary outcomes collected from each group were percent survival at one and three years respectively.
Results: 27 patients were included in the study. The most common source of post SIT infection was intrabdominal which comprised of 29.6% (n=8) of all infections. From this group, 88% developed infections within 6 months of SIT with a one and three-year survival rate of 86% respectively. 13% developed after 12 months, having a 100% survival rate after one and three years respectively. The second most common source was CMV viremia which comprised 19% of infections with 20% of these patients developing within 6-12 months from SIT with a one-year survival of 100% and three-year survival of 0%. From patients who developed CMV viremia, 80% of them developed it after 12 months from SIT, and survival rate at three years was 100%. The next group of infections was pneumonia which comprised of 15% of patients (n=4). 75% (n=3) developed within six months of SIT and three-year survival rate was 100%. 25% (n=1) of them developed 6-12 months after SIT and had a one-year survival rate of 100% with a three-year survival rate of 0%.
Discussion: Of patients who developed post SIT infections, intrabdominal infections were the most common with most patients developing them within six months from SIT. Common causes from this group included intraabdominal abscess’, fluid translocation, peritonitis, and enteritis. While CMV viremia was the second most common infection, the source and site of infection was largely unknown and could have had overlap from patient’s with intrabdominal infection. Larger studies from multi center are needed for further investigation of infectious complications following SIT.
Disclosures:
Momin Samad indicated no relevant financial relationships.
Momin Samad, MD1, Syed-Mohammed Jafri, MD2. P1245 - An Evaluation of Infections and Outcomes Following Intestinal Transplantation, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.
