Sahla Hammad, MD1, Moeez Akram, MBBS2, Hafsa Azam, 3, Muhammad Rehman, 3, Muhammad Waqas Tahir, MD4, Arsalan Zafar Iqbal, 5, Yousaf Zafar, MD6 1Atrium Health, Charlotte, NC; 2Allama Iqbal Medical College, Lahore, Punjab, Pakistan; 3Jinnah Sindh Medical University, Karachi, Sindh, Pakistan; 4Mayo Clinic Florida, Jacksonville, FL; 5University of Mississippi Medical Center, Karachi, Sindh, Pakistan; 6University of Mississippi Medical Center, Jackson, MS
Introduction: Barrett's esophagus is a precancerous condition in which the distal esophagus develops metaplastic columnar epithelium in place of the healthy squamous epithelium. To reduce the risk of Barrett's esophagus the use of nonsteroidal anti-inflammatory medicines (NSAIDs) has been proposed as a therapeutic strategy. However, previous research on the topic has produced inconsistent results, necessitating a comprehensive meta-analysis.
Methods: Barrett's esophagus is a precancerous condition in which the distal esophagus develops metaplastic columnar epithelium in place of the healthy squamous epithelium. To reduce the risk of Barrett's esophagus the use of nonsteroidal anti-inflammatory medicines (NSAIDs) has been proposed as a therapeutic strategy. However, previous research on the topic has produced inconsistent results, necessitating a comprehensive meta-analysis.
Results: A total of 10 studies were included in our meta-analysis. The pooled analysis revealed a significant association between NSAID use and reduced risk of Barrett’s esophagus (OR: 0.82, 95% CI: 0.71–0.95). Furthermore, subgroup analysis revealed that aspirin can lower the risk of Barrett's esophagus (OR: 0.73, 95% CI: 0.61–0.89). Although this association was not evident for non-aspirin NSAIDs (OR: 0.90, 95% CI: 0.74–1.09),
Discussion: This meta-analysis provides strong evidence that the use of NSAIDs is associated with a reduced risk of Barrett's esophagus. The results draw attention to the potential clinical implications of NSAID medication in the management or prevention of this precancerous disease.
Figure: Figure 1: Effect of aspirin and non-aspirin NSAIDs on Barrett’s esophagus.
Disclosures:
Sahla Hammad indicated no relevant financial relationships.
Moeez Akram indicated no relevant financial relationships.
Hafsa Azam indicated no relevant financial relationships.
Muhammad Rehman indicated no relevant financial relationships.
Muhammad Waqas Tahir indicated no relevant financial relationships.
Arsalan Zafar Iqbal indicated no relevant financial relationships.
Yousaf Zafar indicated no relevant financial relationships.
Sahla Hammad, MD1, Moeez Akram, MBBS2, Hafsa Azam, 3, Muhammad Rehman, 3, Muhammad Waqas Tahir, MD4, Arsalan Zafar Iqbal, 5, Yousaf Zafar, MD6. P1845 - Effect of Nonsteroidal Anti-inflammatory Drugs on Barrett’s Esophagus: A Systematic Review and Meta-analysis, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.
