P2642 - National Trends in Clinical Presentation and Complications of Meckel’s Diverticulum in Adults in the United States: A Population-Based Study

Waqas Rasheed, MD¹, Gnanashree Dharmarpandi, MD¹, Muhammad Anil, MD², Shahana ishfaque, MBBS³, Muhammad Anees, MD¹, Sarah Naveed. Qureshi, MBBS^4
1Texas Tech University Health Sciences Center, Amarillo, TX; ²Beaumont Hospital, Dearborn, MI; ³Punjab Medical College, Faisalabad, Pakistan, Dearborn, MI; ⁴CMH Multan Institute of Medical Sciences, Multan, Pakistan, Beaumont, TX

Introduction: Meckel’s diverticulum (MD) is the most common congenital malformation of the gastrointestinal tract. According to previous studies, MD varies in presentation between children and adults, but the rate of particular presentations and complications is not well known. In children, it is well known that the most common presentation of MD is gastrointestinal bleeding, but the applicability of this to adults has been under question. This study aims to investigate the most common complications of MD in adults in the US using the largest inpatient database.

Methods: This retrospective study utilized the National Inpatient Sample (NIS) database from 2016-2020. We included adult patients (age ≥18 years) with MD hospitalized between 2016-2020 and created a table of biodemographic and hospital characteristics using the chi-square test for categorical variables and student’s t-test for continuous variables (Table 1). We also presented the annual trend in inpatient outcomes of MD in a graph (Figure 1).

Results: We identified 24,280 adult patients with a mean age of 54.11 years, mostly white men admitted to large teaching hospitals in the southern region of the US (Table 1). Most patients presented with intestinal obstruction, followed by gastrointestinal bleeding and the rates of these complications have increased over the last two years. Intestinal perforation and volvulus were identified less frequently. MD-related inpatient mortality has improved over the last few years (Figure 1).

Discussion: Meckel’s diverticulum most commonly presented in adults with intestinal obstruction, followed by gastrointestinal bleeding. Gastrointestinal bleeding due to MD is thought to be related to ulceration of the small bowel due to acid secretion by ectopic gastric mucosa within the diverticulum, with the site of bleeding being downstream from the diverticulum. Intestinal obstruction due to MD in children results from intussusception and volvulus. In adults, the obstruction is likely related to torsion of the diverticulum, abdominal wall hernia with incarceration of diverticulum, or diverticulitis resulting in obstruction of the bowel lumen. The risk factors for some of the causes of intestinal obstruction such as abdominal wall hernia and diverticulitis are more common in adults and this likely results in intestinal obstructions as the most common presentation of MD.



Disclosures:


Waqas Rasheed, MD¹, Gnanashree Dharmarpandi, MD¹, Muhammad Anil, MD², Shahana ishfaque, MBBS³, Muhammad Anees, MD¹, Sarah Naveed. Qureshi, MBBS⁴. P2642 - National Trends in Clinical Presentation and Complications of Meckel’s Diverticulum in Adults in the United States: A Population-Based Study, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.