Monday Poster Session
Category: Stomach
Malek Shatila, MD
University of Texas MD Anderson Cancer Center
Houston, Texas
Table 1a. Multivariate Cox Hazard analysis for 3- and 5-year survival among patients on ICI, n=200 | ||||
| 3-year survival | 5-year survival | ||
Variable | Hazard ratio | p-value | Hazard ratio | p-value |
Age | 0.9(0.9-0.9) | 0.006* | 0.9(0.9-0.9) | 0.018* |
Hp+ vs. Hp- | 2.0(1.0-4.0) | 0.041*1 | 1.5(0.8-2.6) | 0.224 |
Mucinous vs. non-mucinous adenocarcinoma | 0.4(0.2-0.9) | 0.042* | 0.5(0.2-0.9) | 0.049* |
Race: Asian vs. non-Asian2 | 0.7(0.4-1.3) | 0.239 | - | - |
Presence of other cancers (concurrent or preceding gastric cancer)2 | 1.4(0.7-2.8) | 0.292 | - | - |
Table 1b. Multivariate Cox Hazard analysis for 10-year survival among patients with and without Hp | ||||
| Hp- n=2734 | Hp+ n=195 | ||
Variable | Hazard ratio | p-value | Hazard ratio | p-value |
Age | 0.9(0.9-0.9) | 0.000* | 0.9(0.9-0.9) | 0.006* |
Mucinous vs. non-mucinous adenocarcinoma | 0.9(0.8-1.0) | 0.120 | 0.5(0.2-0.8) | 0.013* |
Receiving ICI vs. no ICI | 1.8(1.4-2.3) | 0.000* | 2.2(1.2-4.2) | 0.006* |
Abbreviations: ICI = immune checkpoint inhibitors, Hp = Helicobacter pylori *Significant at the p< 0.05 level. 1Running the same analysis for patients not on ICI, findings were similar except for Hp seropositivity, which was no longer significant (p=0.325). 2These variables were excluded from the analysis at 5-years given their lack of significance at the 3-year analysis. |