P3012 - The Efficacy and Safety of Vibrating Capsules for Chronic Idiopathic Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abdallah Saeed, MD¹, Mohamed Abuelazm, MBBCh², Mohamed Abdelnabi, MD³, Mariam Elewidi, MD¹, Asmaa Khaled, MD¹, Amr Alzahaby, MD¹, Amr Mousa, MD¹, Islam Mohamed, MD⁴, Basel Abdelazeem, MD^5
1Tanta University, Tanta, Al Qahirah, Egypt; ²Tanta University, Tanta, Al Gharbiyah, Egypt; ³University of Michigan, Ann Arbor, MI; ⁴University of Missouri-Kansas City, Kansas City, MO; ⁵McLaren Health Care, Michigan State University, Flint, MI

Introduction: Chronic idiopathic constipation (CIC) is a prevalent worldwide functional gastrointestinal disorder that remains challenging to treat. Pharmacologic therapy, such as laxatives and dietary fibers are suggested as lines of treatment. However, these lines are not effective enough. Novel emergent orally ingested vibrating capsules (VC) are introduced as a possible line for management for CIC.

Methods: We conducted a literature search in English on electronic databases CENTRAL, PubMed, EMBASE, Scopus, and WOS until February 27th, 2023. RevMan was used to pool dichotomous outcomes as risk ratios (RRs) and continuous outcomes as mean differences (MDs), with 95% confidence intervals (CIs). The study protocol was registered in PROSPERO with ID: (CRD42023409422).

Results: Three RCTs with a total of 601 patients were included in our analysis. There was no difference between the VC and placebo in increased complete spontaneous bowel movements (CSBM) (responder rate) (RR: 1.37 with 95% CI [0.82, 2.28], P = 0.22), CSBM change (MD: 0.21 with 95% CI [-0.26, 0.69], P=0.38), spontaneous bowel movement (SBM) change (MD: 0.14 with 95% CI [-0.22, 0.49], P= 0.46), and the incidence of any adverse event (RR: 1.45 with a 95% CI of [0.79, 2.63], P = 0.23). However, VC was associated with increased vibration sensation (RR: 17.23, 95% CI [3.29, 90.20], P = 0.0008).

Discussion: VC may positively impact improving bowel movements and relieving symptoms of CIC. Our findings suggest that VC is safe and well-tolerated, with no significant harmful effects observed. However, more research is needed to confirm these results and determine the most effective dose, frequency, and duration of treatment for VC to maximize their benefits without compromising safety.



Disclosures:


Abdallah Saeed, MD¹, Mohamed Abuelazm, MBBCh², Mohamed Abdelnabi, MD³, Mariam Elewidi, MD¹, Asmaa Khaled, MD¹, Amr Alzahaby, MD¹, Amr Mousa, MD¹, Islam Mohamed, MD⁴, Basel Abdelazeem, MD⁵. P3012 - The Efficacy and Safety of Vibrating Capsules for Chronic Idiopathic Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.