P2856 - Diabetic Patients Are More Likely to Develop Pancreatic Cysts Than Non-Diabetic Patients

Ethan Berman, MD¹, Lindsay Donnelly, MD², Hassam Ali, MD³, Pratik Patel, MD^2
1Northwell Health/Hofstra Zucker School of Medicine, Manhasset, NY; ²Mather Hospital/Hofstra University Zucker School of Medicine, Port Jefferson, NY; ³East Carolina University Medical Center, Greenville, NC

Introduction: It has previously been reported that patients with uncontrolled diabetes mellitus may have an increased propensity for developing pancreatic cysts. We aimed to evaluate the prevalence of pancreatic cysts in diabetic patients compared to those without diabetes among hospitalized patients in the United States.

Methods: We used the National Inpatient Sample (NIS) database to analyze hospitalizations with a diagnosis (primary or secondary) of pancreatic cyst from 2016-2020. The primary outcome included comparative trends in pancreatic cysts based on diabetes as a comorbidity. The secondary outcome measured the association between pancreatic cysts and diabetes. Patients < 18 years of age were excluded. Kruskal-Wallis test for continuous variables, the Chi-square test for categorical variables, and the Non-parametric trend test was used to report linear trends using statistical software for data science (STATA version 16). Logistic regression outcomes were reported as Odd ratios (OR) with 95% confidence intervals (95% CI).

Results: There were 162,460 weighted hospitalizations with pancreatic cysts in the US from 2016 to 2019 (Diabetes = 34.7%; No Diabetes = 65.3%). The overall rate of pancreatic cysts was 109 per 100,000 total NIS hospitalizations. This rate was higher in patients with Diabetes (139/100,000 total NIS hospitalizations) than those without diabetes (97.8/100,000 total NIS hospitalizations). The overall rate of pancreatic cysts increased from 84.9/100,000 total NIS hospitalizations in 2016 to 141.1/100,000 total NIS hospitalizations in 2020.

The rate of pancreatic cysts in diabetic patients increased from 108.4/100,000 total NIS hospitalizations in 2016 to 177.3/100,000 total NIS hospitalizations in 2020. The rate of pancreatic cysts in non-diabetic patients increased from 76.6/100,000 total NIS hospitalizations in 2016 to 126.7/100,000 total NIS hospitalizations in 2020. Patients with Diabetes had a higher association with pancreatic cysts than non-diabetics (OR 1.76 [95% CI, 1.72-1.80], P < 0.001).

Discussion: There is a rising trend in the overall prevalence of pancreatic cysts in the hospitalized United States population. Diabetic patients have a significantly increased association of pancreatic cysts in comparison to non-diabetic patients. More research is needed to determine if diabetic patients require closer surveillance of pancreatic cysts.



Disclosures:


Ethan Berman, MD¹, Lindsay Donnelly, MD², Hassam Ali, MD³, Pratik Patel, MD². P2856 - Diabetic Patients Are More Likely to Develop Pancreatic Cysts Than Non-Diabetic Patients, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.