University of Mississippi Medical Center Jackson, MS
Himmat Brar, MD1, Muhammad Rehman, 2, Hafsa Azam, 2, Syed Sarmad Javaid, 2, Arsalan Zafar Iqbal, 3, Yousaf Zafar, MD1 1University of Mississippi Medical Center, Jackson, MS; 2Jinnah Sindh Medical University, Karachi, Sindh, Pakistan; 3University of Mississippi Medical Center, Karachi, Sindh, Pakistan
Introduction: NAFLD and urolithiasis are common disorders with serious health consequences.Urolithiasis refers to the development of urinary stones, whereas NAFLD refers to excessive liver fat storage. There is conflicting information about the relationship between NAFLD and urolithiasis. The purpose of this meta-analysis is to thoroughly examine this link.
Methods: PubMed and Google Scholar were systematically searched for observational studies, from inception till 13 May 2023 to identify all studies that compared the risk of urolithiasis among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance model, and odds ratios (ORs) were pooled with their 95% confidence intervals (CI).
Results: In our meta-analysis, 11 observational studies were included with a total population of 31551 participants of which 8460 had NAFLD.NAFLD was significantly associated with an increased risk of urolithiasis (random effect odds ratio, OR 2.40, 95% confidence interval, CI 1.71-3.37, I2=90%). This association persisted in males (OR 2.81 CI 1.64-4.81, I2=93%), as well as in females (OR 2.93 CI 1.86-4.62, I2=80%).
Discussion: The pooled analysis shows a significant correlation between NAFLD and a higher risk of urolithiasis. These findings imply that NAFLD may pose as a serious risk factor for the emergence of urolithiasis and hence emphasize the importance of further research to understand the underlying mechanisms linking NAFLD and urolithiasis.
Figure: Figure 1. Risk of urolithiasis in NAFLD patients. Figure 2. Risk of urolithiasis in NAFLD patients. (Males). Figure 3. Risk of urolithiasis in NAFLD patients. (Females)
Disclosures:
Himmat Brar indicated no relevant financial relationships.
Muhammad Rehman indicated no relevant financial relationships.
Hafsa Azam indicated no relevant financial relationships.
Syed Sarmad Javaid indicated no relevant financial relationships.
Arsalan Zafar Iqbal indicated no relevant financial relationships.
Yousaf Zafar indicated no relevant financial relationships.
Himmat Brar, MD1, Muhammad Rehman, 2, Hafsa Azam, 2, Syed Sarmad Javaid, 2, Arsalan Zafar Iqbal, 3, Yousaf Zafar, MD1. P3866 - Risk of Urolithiasis and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.
