Huzaifa Ahmad Cheema, MBBS1, Abia Shahid, MBBS1, Muhammad Ehsan, MBBS1, Tajamal Hayat, MBBS1, Muhammad Ayyan, MBBS1, Ambreen Nabeel, MBBS2, Rehmat Ullah Awan, MD2, Hrishikesh Samant, MD3, Ayokunle T.. Abegunde, MD4 1King Edward Medical University, Lahore, Punjab, Pakistan; 2Ochsner Rush Medical Center, Meridian, MS; 3Ochsner Medical Center, New Orleans, LA; 4Loyola University Medical Center, Maywood, IL
Introduction: Enteropathy-associated T-cell lymphoma (EATL) is a type of non-Hodgkin lymphoma that occurs in the intestinal tract. It is a rare but lethal tumor with a reported median survival time of approximately 10 months. Due to the limited data available, we conducted a time trend analysis of EATL mortality rates in the US.
Methods: Using data from the Surveillance, Epidemiology, and End Results (SEER) database, we assessed the incidence-based mortality (IBM) and survival rates of EATL between 2000 and 2020. We calculated age-adjusted IBM rates per 1,000,000 population, and IBM rate ratios (RRs) for different age groups, genders, and races using SEER*Stat program version 8.4.1.2. We also retrieved overall and summary stage-specific survival rates. We analyzed overall, and age- and sex-specific trends of the IBM rates of EATL using Joinpoint Regression program version 5.0.2, and calculated annual percentage change (APC) and average annual percentage change (AAPC). A P-value < 0.05 was considered statistically significant.
Results: From 2000 to 2020, a total of 326 EATL-specific deaths occurred with an annual IBM rate of 0.116 per 1,000,000. Overall, the IBM rate of EATL increased 59.49% per year between 2000 and 2003 (P < 0.05) but remained stable after that (APC 1.66%; P >0.05) with an AAPC of 8.77% (95% CI: 4.07%-15.84%; P < 0.05) (Figure 1). The IBM rates for patients with ages less than 60 years remained stable (AAPC 0.06%; P >0.05) while for those aged 60 years and older, the IBM rates increased by an average of 11.76% per year (AAPC difference 11.70%; P < 0.05). Females had a significantly lower IBM as compared to males (RR 0.52, 95% CI: 0.42-0.66; P < 0.001). When compared to Whites, only Asians or Pacific Islanders had significantly higher IBM rates (RR 1.81, 95% CI: 1.27-2.53; P < 0.05) while Blacks and American Indians/Alaska Natives had similar rates. The observed age-standardized overall 1- and 5-year survival rates were 37.9% and 17.1%, respectively. The 5-year survival rates for localized, regional, and distant cancers were 26.0%, 18.6%, and 10.2%, respectively.
Discussion: Although the overall IBM of EATL has remained stable after 2003, there is an upward trend in mortality rates in elderly patients ( >60 years) with a large increase in IBM per year. Additionally, male sex and Asian or Pacific Islander race are associated with worse prognosis.
Figure: Figure 1: Age-adjusted incidence-based mortality rates per 1,000,000 population for enteropathy-associated T-cell lymphoma (EATL) in the US between 2000 and 2020.
Disclosures:
Huzaifa Ahmad Cheema indicated no relevant financial relationships.
Abia Shahid indicated no relevant financial relationships.
Muhammad Ehsan indicated no relevant financial relationships.
Tajamal Hayat indicated no relevant financial relationships.
Muhammad Ayyan indicated no relevant financial relationships.
Ambreen Nabeel indicated no relevant financial relationships.
Rehmat Ullah Awan indicated no relevant financial relationships.
Hrishikesh Samant indicated no relevant financial relationships.
Ayokunle Abegunde indicated no relevant financial relationships.
Huzaifa Ahmad Cheema, MBBS1, Abia Shahid, MBBS1, Muhammad Ehsan, MBBS1, Tajamal Hayat, MBBS1, Muhammad Ayyan, MBBS1, Ambreen Nabeel, MBBS2, Rehmat Ullah Awan, MD2, Hrishikesh Samant, MD3, Ayokunle T.. Abegunde, MD4. P3025 - Trends in the Mortality of Enteropathy-Associated T-cell Lymphoma in the US, 2000-2020: A Population-Based Analysis, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.
