Lawrence R. Kosinski, MD, MBA, FACG1, Joel Brill, MD2, Omer Shahab, MD3, David Lieberman, MD4, Charlie Baum, MD5, Alexander Kanute, BS6, Leanne Metcalfe, PhD7, Sachin Singh, BS, MS8, Ali Keshavarzian, MD9, Michelle Villanueva, MS9, Heather Rasmussen, PhD, RD10, Angel Perales, 9 1VOCnomics, Scottsdale, AZ; 2Predictive Health, Paradise Valley, AZ; 3VHC Health, Arlington, VA; 4Oregon Health & Science University, Portland, OR; 5Encore Health, Chicago, IL; 6Vocnomics, Chicago, IL; 7UT Tyler Health Sciences Center, Austin, TX; 8SonarMD, Chicago, IL; 9Rush University Medical Center, Chicago, IL; 10University of Nebraska-Lincoln, Lincoln, NE
Introduction: The gut microbiome (GM) exhibits multifunctional redundancy due to different bacteria sharing a capacity for similar metabolic function. Despite an extreme diversity in taxonomy, metabolic function is much less diverse. Fecal metabolomics, the quantification of GM metabolites, has demonstrated profiles for health and disease. Patterns of volatile organic compounds (VOCs) produced by the metabolome have demonstrated the ability to separate patients with Inflammatory Bowel Disease from healthy controls. Unfortunately, this requires sophisticated testing that is not available in a home setting. We developed a novel prototype e-nose using a multi-pixel gas sensor that passively collects VOC data. When placed in proximity to a commode, it collects post-defecation VOCs and sends this data to a cloud-based server for analysis of fermentable fiber intake. The feasibility of our device was tested in two IRB approved studies.
Methods: In Study 1, ten healthy couples participated in a two-week study where each couple placed an e-nose in their bathroom within 6 feet of the commode. The device contains two separate buttons which when pressed before a bowel movement identifies each user. Each subject also maintained a food log using the Livestrong/MyPlate app which measured fiber intake. In Study 2, five subjects monitored their fiber intake and VOC output similar to Study 1, before and after 1 week of a 10 gram prebiotic fiber supplement daily.
Results: Study 1. Eight of the ten couples completed the study, but only nine subjects completed at least 12 days of their food log and data analysis. These nine subjects are the basis of our study. The results are shown in Table 1 and Figure 1. Using Min/Max normalization, there is a postive direct correlation (r=0.21) between fiber intake and VOC output. Study 2. A modest and significant corrrelation (r=0.51) was obtained in week 1. In week 2, the VOC of four of the five subjects rose in conjunction with ingestion of the fiber bar.
Discussion: These studies demonstrates that a prototype e-nose can noninvasively produce a direct correlation between fiber intake and VOC output in a home-based environment. The ability to assess the fermentable activity of the fecal metabolome on an ambulatory basis could create a new digital health opportunity to evaluate, monitor and manage fiber intake and gut health. It may also represent a remote patient monitoring tool for GIs.
Figure: Figure 1
Disclosures:
Lawrence Kosinski: Capstan.ai – Advisor or Review Panel Member, Owner/Ownership Interest. Jona – Advisor or Review Panel Member, Consultant, Owner/Ownership Interest. SonarMD – Employee, Owner/Ownership Interest. VOCnomics, LLC – Employee, Intellectual Property/Patents, Owner/Ownership Interest.
Joel Brill: Alimetry – Consultant. AnX Robotica – Consultant. Arch Therapeutics – Consultant. Arthrex – Consultant. ATMO Biosciences – Consultant. Autem Therapeutics – Consultant. Bigfoot Medical – Consultant. BiotaX – Consultant. Boomerang Medical – Consultant. Brightline – Consultant. BrightUro – Consultant. Capsovision – Consultant. CheckCap – Consultant. CuraFi – Consultant. DeOro Devices – Consultant. Docbot – Consultant. EchoPixel – Consultant. EndoGastric Solutions – Consultant. Endosound – Consultant. Endosure – Consultant. Equanimity AI – Consultant. Family First – Consultant. Food Marble – Consultant. Freespira – Consultant. Gait Better – Consultant. Galvanize Therapeutics – Consultant. GI View – Consultant. Gilead – Consultant. Glaukos – Consultant. GT Medical – Consultant. gTech Health – Consultant. GTI Laboratories – Consultant. Gynesonics – Consultant. Hello Heart – Consultant. Hemwell – Consultant. Hygieacare – Consultant. Impedimed – Consultant. Imvaria – Consultant. Intrinsic Therapeutics – Consultant. Lantheus Medical Imaging – Consultant. Limaca Medical – Consultant. LimbicAi – Consultant. Lucid Diagnostics – Consultant. Mahana Therapeutics – Consultant. MaternaMed – Consultant. Medtronic – Consultant. Modify Health – Consultant. Neuraxis – Consultant. Neuromotion Labs – Consultant. Noah Medical – Consultant. Novocuff – Consultant. Nuviera – Consultant. Omnia Medical – Consultant. Optellum – Consultant. OTTek – Consultant. Penguin Smart – Consultant. Pentaomix – Consultant. Perry Health – Consultant. Perspectum – Consultant. Prophase Labs – Consultant. Reflexion – Consultant. Restalsis – Consultant. Salaso Health Solutions Ltd. – Consultant. Samay Health – Consultant. Satisfai Health – Consultant. Shockwave Medical – Consultant. SI Bone – Consultant. SonarMD – Advisory Committee/Board Member. Sonic Incytes – Consultant. SonioSAS – Consultant. Stage Zero Life Sciences – Consultant. Steris – Consultant. Surgimatix – Consultant. Sword Health – Consultant. The Insides Company – Consultant. The Lactation Network – Consultant. Therapixel – Consultant. ThermoFisher – Consultant. TwinHealth – Consultant. Vertos Medical – Consultant. Vivante Health – Advisor or Review Panel Member. WIld Health – Consultant. WL Gore – Consultant.
Omer Shahab indicated no relevant financial relationships.
David Lieberman: ColoWrap – Advisory Committee/Board Member. Geneoscopy – Advisor or Review Panel Member. UDX – Consultant.
Charlie Baum indicated no relevant financial relationships.
Alexander Kanute indicated no relevant financial relationships.
Leanne Metcalfe indicated no relevant financial relationships.
Sachin Singh indicated no relevant financial relationships.
Ali Keshavarzian indicated no relevant financial relationships.
Michelle Villanueva indicated no relevant financial relationships.
Heather Rasmussen indicated no relevant financial relationships.
Angel Perales indicated no relevant financial relationships.
Lawrence R. Kosinski, MD, MBA, FACG1, Joel Brill, MD2, Omer Shahab, MD3, David Lieberman, MD4, Charlie Baum, MD5, Alexander Kanute, BS6, Leanne Metcalfe, PhD7, Sachin Singh, BS, MS8, Ali Keshavarzian, MD9, Michelle Villanueva, MS9, Heather Rasmussen, PhD, RD10, Angel Perales, 9. P3026 - Measurement of Fecal Volatile Organic Compounds Using a Passive Electronic Nose: Home-Based Test, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.