P4168 - Asymptomatic Recurrent Idiopathic Pneumoperitoneum: A Rare Case Presentation

Mary Vetter, ANPC¹, Sarah Enslin, PA-C¹, Victoria Howard, PA-C¹, Michael Colicchio, PA-C², Michael J. Nabozny, MD³, Patrick Fultz, MD¹, Derrick German, MD¹, Shivangi Kothari, MD^3
1University of Rochester Medical Center, Rochester, NY; ²URMC, Rochester, NY; ³University of Rochester, Rochester, NY

Introduction: Abdominal pneumoperitoneum is often caused by perforated abdominal viscus. Other causes include bowel obstruction, appendicitis, neoplasm, vasculitis, and infection. Presentation varies from asymptomatic to life-threatening sepsis and may warrant emergent surgical intervention. Recurrent idiopathic pneumoperitoneum is a very rare disorder described in only a few case reports in literature. We present a case of asymptomatic recurrent idiopathic pneumoperitoneum.

Case Description/Methods: 56-year-old M with h/o chronic pain, GERD and constipation presented with hand and rib pain after a fall on a sidewalk. Abdominal x-ray showed massive pneumoperitoneum and dilated loops of small bowel. CT scan confirmed pneumoperitoneum and no evidence of bowel obstruction. Labs including CBC and CMP were within normal range. CRP was 9mg/L (normal < 8 mg/L). Repeat CT scan the next day showed stable findings. Patient had no abdominal pain or fever. Patient was discharged home, asymptomatic and hemodynamically stable. CT one month later showed persistent large amount of free intraperitoneal air (Image 1). Patient remained completely asymptomatic. Surgical consult obtained and no surgery was recommended. Leading diagnosis was pneumatosis cystoids intestinalis and patient treated empirically with antibiotics (metronidazole). Evaluation including upper GI small bowel follow through, colonoscopy, EGD and gastrograffin enema did not reveal any pathology to explain pneumoperitoneum. Chest CT and serologic work-up (ANA, SSA, SSB, RNP, dsDNA, C3, C4, ANCA, MPO, PR3) ruled out pulmonary etiology, connection tissue disorder and vasculitis. CT enterography 1 month later showed resolution of pneumoperitoneum (Image 2). CT 3 months later showed recurrent large amount of free intraperitoneal air (Image 3). Patient was re-referred for surgical evaluation. After multidisciplinary discussion with surgery and radiology, he underwent laparoscopy, EGD and flexible sigmoidoscopy; no air leak, cyst or serosal defect was seen. Patient has continued to do well without additional intervention.

Discussion: Asymptomatic, recurrent idiopathic pneumoperitoneum is a rare disorder and identifying the etiology can be challenging/anxiety provoking for the patient and provider. Data is very limited but suggests that patients may do well with conservative therapy. Given the rarity of this diagnosis, extensive evaluation and multidisciplinary approach is essential in the diagnosis and management of these patients.



Disclosures:


Mary Vetter, ANPC¹, Sarah Enslin, PA-C¹, Victoria Howard, PA-C¹, Michael Colicchio, PA-C², Michael J. Nabozny, MD³, Patrick Fultz, MD¹, Derrick German, MD¹, Shivangi Kothari, MD³. P4168 - Asymptomatic Recurrent Idiopathic Pneumoperitoneum: A Rare Case Presentation, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.