P3173 - Between the Cheeks: An Exploration of Incidence Trends of Anus, Anal Canal, and Rectal Cancer in the United States

Brett A. Dinner, MD¹, Taylor Viggiano, MD², Phillip Leff, DO¹, Ericka Charley, MD³, Matthew M. Barvo, MD¹, Keng-Yu Chuang, MD^4
1Creighton University, Phoenix, AZ; ²Mayo Clinic Arizona, Scottsdale, AZ; ³Creighton University Phoenix, Mesa, AZ; ⁴Valleywise Health, Phoenix, AZ

Introduction: The incidence of cancer involving the anus, anal canal, and rectum (AC) has been rising over a few decades. In the United States, these cancers are rare and represent less than 2% of all intestinal cancers with less than 10,000 new cases annually. They typically present as squamous cell carcinoma and rarely as adenocarcinoma or other non-epidermoid cancers. This study aims to compare the temporal change in the incidence rate (IR) of AC across different genders and races over the past two decades.

Methods: The Surveillance, Epidemiology, and End Results Program (SEER) database was queried for incidence rates (IR) of AC in different genders and races between 2000-2020. IR were collected. Mean IRs, P values, and slope were compared between gender and the following races: Asian / Pacific Islander (Non-Hispanic), Black (includes Hispanic), Hispanic (any race), Non-Hispanic White, and White (includes Hispanic). T-test were used to calculate significance.

Results: The mean IR of AC among various ethnicities are summarized in Table 1. (Incidence Rate of Reported Cases of AC Between 2000-2020 per 100,000.)

The IR of AC is higher in non-Hispanic White women compared to other groups and male gender (P< 0.001) with the exception of White (includes Hispanic) women and Black (includes Hispanic) men. Among men, the IR of AC is highest in the Black (includes Hispanic) population relative to other races (P< 0.001). In the Hispanic (any race), Non-Hispanic White, and White (includes Hispanic) populations, the IR is higher in women versus men (P< 0.001), yet higher in men compared to women of the Black (includes Hispanic) race (P< 0.001).

Over the last two decades (2000-2020), the IR correlation was positive in Black (includes Hispanic), Hispanic (any race), Non-Hispanic White, and White (includes Hispanic) males and females and negative for Asian Pacific Islander (non-Hispanic) males and females. IR correlation was negative for Asian / Pacific Islander (non-Hispanic) males and females.

Discussion: IRs of AC are highest in White women and Black men and are increasing among both genders of the Black, Hispanic and White races. To reduce the IR of AC, attention should be focused on screening those with risk factors, ensuring vaccination per Advisory Committee on Immunization Practices guidelines, promoting the use of barrier contraception, and encouraging smoking cessation. Increased employment of anoscopy and sigmoidoscopy can be considered in these groups.


Disclosures:


Brett A. Dinner, MD¹, Taylor Viggiano, MD², Phillip Leff, DO¹, Ericka Charley, MD³, Matthew M. Barvo, MD¹, Keng-Yu Chuang, MD⁴. P3173 - Between the Cheeks: An Exploration of Incidence Trends of Anus, Anal Canal, and Rectal Cancer in the United States, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.