Justin Tin, 1, Zaki Masoud, BA, MD2, Siying Chen, BS3, YuFei Lin, 4, Kevin Tin, MD, MBA5 1Newtown Gastroenterology, Queens, NY; 2NYU Langone, Albertson, NY; 3University at Buffalo, Elmhurst, NY; 4Queens College, Flushing, NY; 5Newtown Gastroenterology PC, New Hyde Park, NY
Introduction: Recently, there has been a significant increase in the consumption of ultra-processed foods worldwide. However, the association between the consumption of ultra-processed food, obesity, and the prevalence of colon cancer remains controversial.
Methods: A comprehensive systematic literature search of PubMed, Scopus, Web of Science, and google scholar for grey literature was done for articles published before 8th March 2023. The search was done to retrieve potential peer-reviewed articles that explored the association between the consumption of ultra-processed food, obesity, and the prevalence of colon cancer.
Results: Of the 246 potential articles assessed,17 met the inclusion criteria. Meta-analysis results demonstrated that high consumption of ultra-processed food is associated with an increased risk of obesity (odds ratio: 1.65; 95% [CI], 1.07-2.45; P < 0.05). Consequently, there is a positive association between obesity and an increased risk of colon cancer (odds ratio: 1.48; 95% confidence interval [CI], 0.77-2.87; P > 0.05).
Discussion: Obesity, overweight, and the risk of colon cancer can be minimized by reducing the consumption of ultra-processed foods and promoting a healthy diet and lifestyle. The diet should contain fruits, vegetables, whole grains, and lean proteins. Public health initiatives and government policies may also play a crucial role in reducing the consumption of ultra-processed foods and drinks and encouraging healthier dietary choices. Consuming ultra-processed foods increases the risk of obesity and colon cancer.
Figure: Figure 1. Forest Plot of meta-analysis comparing higher vs. lower consumption of ultra-processed food and obesity risk in adults. Figure 2. Forest Plot of meta-analysis comparing obesity vs. healthy weight and colon cancer risk in adults.
Disclosures:
Justin Tin indicated no relevant financial relationships.
Zaki Masoud indicated no relevant financial relationships.
Siying Chen indicated no relevant financial relationships.
YuFei Lin indicated no relevant financial relationships.
Kevin Tin indicated no relevant financial relationships.
Justin Tin, 1, Zaki Masoud, BA, MD2, Siying Chen, BS3, YuFei Lin, 4, Kevin Tin, MD, MBA5. P3191 - Ultra-Processed Food, Obesity, and Colon Cancer: A Systematic Review and Meta-Analysis, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.
