Justin Tin, 1, Andrew Chow, BS1, Grace Lin, 1, Josh Li, 2, Kevin Tin, MD, MBA3 1Newtown Gastroenterology, Queens, NY; 2New Town Gastroenterology, Elmhurst, NY; 3Newtown Gastroenterology PC, New Hyde Park, NY
Introduction: There has been mixed evidence regarding the relationship between shorter sleep duration and the risk of colorectal cancer. The objective of the current systematic review and meta-analysis was to assess the relationship between colorectal cancer and lack of sleep.
Methods: Literature search was done on PubMed, Embase, Scopus, Web of Science and Cochrane library databases for English articles with full texts available online. Systematic reviews, meta-analysis, evidence syntheses, editorials, commentaries, preclinical studies, abstracts, theses and preprints were excluded. The review manager software was used to conduct a prevalence meta-analysis.
Results: Databases including PubMed, Web of Science, Scopus, Embase and Cochrane library were searched. Initially, 1494 articles were initially identified. After the elimination of duplicates and analysis of the remaining articles with respect to the inclusion and exclusion criteria, 9 articles remained.
Discussion: All the studies included in the current systematic review and meta-analysis reported data related to lack of sleep and risk of colorectal cancer. Most of the studies reported that there is a positive correlation between lack of sleep and colorectal cancer risk. Some studies found contradicting evidence suggesting that lack of sleep does not increase the risk of thyroid cancer; as mentioned earlier, this may be explained by the fact sleep duration were assessed by questionnaire, which likely resulted in non-differential exposure misclassification. The findings suggested that there is positive correlation between lack of sleep and the risk of colorectal cancer. However further studies are needed to confirm these findings.
Figure: Figure 1. Forest plot of comparison: lack of sleep/insomnia and colorectal cancer
Disclosures:
Justin Tin indicated no relevant financial relationships.
Andrew Chow indicated no relevant financial relationships.
Grace Lin indicated no relevant financial relationships.
Josh Li indicated no relevant financial relationships.
Kevin Tin indicated no relevant financial relationships.
Justin Tin, 1, Andrew Chow, BS1, Grace Lin, 1, Josh Li, 2, Kevin Tin, MD, MBA3. P3192 - Lack of Sleep/Insomnia and Colorectal Polyps or Colorectal Cancer Risk: A Systematic Review and Meta-Analysis, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.
