P3361 - Prevalence of Ehlers-Danlos Syndrome (EDS) and Hypermobile EDS, Associated Rates of Rome IV Irritable Bowel Syndrome (IBS), and Relationships of IBS with Global Health, and Psychological Symptoms in the United States

Abid Ahmad, MD, John Venezia, , Jhalka Kadariya, MPH, Huiping Xu, PhD, Andrea Shin, MD
Indiana University, Indianapolis, IN

Introduction: Background: Case-control studies have reported high rates of irritable bowel syndrome (IBS) in hypermobile Ehlers Danlos Syndrome (hEDS). However, the burden of IBS and its impact on quality of life (QoL) or psychological health in non-selected adults with EDS/hEDS compared to the general population is unknown. We aimed to assess prevalence IBS in adults with and without EDS/hEDS and associations with global health and psychological symptoms.

Methods: We conducted an online survey in U.S. adults ≥ 18 years. The survey included the Rome IV Questionnaire, Hospital Anxiety and Depression Scale (HADS), 10-item Patient-Reported Outcome Measurement Information System, questions targeting the 2017 hEDS diagnostic criteria and on socio-demographics. We assessed prevalence of EDS/hEDS. We compared clinical characteristics, prevalence of Rome-IV IBS, global health scores, and HADS scores between EDS/hEDS and controls using two-sample t-tests and Pearson’s chi-square or Fisher’s exact tests. Adjusted linear regression was performed to compare the impact of IBS on global health and psychological factors. Subgroup comparisons were conducted across subjects with non hypermobile EDS, hEDS, and controls.

Results: Results: Of 1193 subjects (40.7% female, 82.1% white, mean age [± standard deviation] 35.3 [± 10.3] years) who completed the survey (Table), 41% satisfied diagnostic criteria for hEDS or had self-reported EDS (n=82 non-hypermobile). More subjects (p< 0.001) with EDS/hEDS (33.3%) fulfilled Rome IV IBS criteria than controls (9.8%). Subjects with EDS/hEDS had higher HADS and lower physical and mental QoL scores than controls (all p< 0.001). Rates of IBS (35.8%) and abnormal anxiety (26.9%) and depression scores (77.0%) in hEDS and non-hypermobile EDS (20.7% IBS, 25.6% abnormal anxiety, 69.5% abnormal depression) were higher than in controls (all overall p< 0.001). In adjusted linear regression analyses, IBS was associated with higher depression (p≤0.001) in all subjects. The effect of IBS on mental and physical health differed between groups; IBS was associated with lower physical health in controls but not in EDS/hEDS (Figure). Adjusted linear regression analysis across subgroups demonstrated differences only in the effect of IBS on mental health (p=0.046).

Discussion: Conclusions: EDS or hEDS is common and associated with high rates of IBS. Although linked to psychological burden and health impairment, the effect IBS on global health is less pronounced in EDS/hEDS than in controls.



Disclosures:


Abid Ahmad, MD, John Venezia, , Jhalka Kadariya, MPH, Huiping Xu, PhD, Andrea Shin, MD. P3361 - Prevalence of Ehlers-Danlos Syndrome (EDS) and Hypermobile EDS, Associated Rates of Rome IV Irritable Bowel Syndrome (IBS), and Relationships of IBS with Global Health, and Psychological Symptoms in the United States, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.