P3530 - How Does Human Immunodeficiency Virus Affect Outcomes in Patients With Inflammatory Bowel Disease? An Analysis of the National Inpatient Sample Data From 2016 to 2020

Mohamed Ahmed, MD¹, Noor Hassan, MD², Khaled Elfert, MD³, Noor Mohamed, MD⁴, Ahmed Elkafrawy, MD⁵, Vinay Jahagirdar, MD², Francis A. Farraye, MD, MSc, MACG⁶, Hassan Ghoz, MD^2
1University of Missouri Kansas City, Overland Park, KS; ²University of Missouri-Kansas City, Kansas City, MO; ³SBH Health System, Bronx, NY; ⁴Alexandria University, Alexandria, Al Iskandariyah, Egypt; ⁵University of Iowa Hospitals & Clinics, Iowa City, IA; ⁶Mayo Clinic, Jacksonville, FL

Introduction: The effect of HIV on IBD has been controversial. The remission hypothesis secondary to CD4 count depletion has been hypothesized but not proven yet. The aim of this study is to examine the characteristics and outcomes of IBD patients with HIV and compare them to IBD patients without HIV.

Methods: Patients hospitalized between 2016 and 2020 who were admitted for Ulcerative colitis (UC) and Crohn’s disease (CD) were identified using International Classification of Diseases Code,10^th Revision Clinical Modification (ICD-10) identified from the Healthcare Cost and Utilization Project databases (HCUP) using the National inpatient sample (NIS). Patients with history of HIV were compared to patients without HIV.

Results: A total number of 410950 patients with history of UC were identified. 1000 patients had a history of HIV. General characteristics are summarized in table 1. HIV patients were younger, less likely to be covered by Medicare and female constituted lower proportion. Mortality rate and length of stay (LOS) were similar in both groups. Patients with UC and history of HIV were more likely to develop ano -rectal abscess. Outcomes are summarized in table 2. Regarding CD, 696500 patients were identified. 790 patients had a history of HIV. Similar to the UC group, patients with CD and HIV were younger, less likely to be covered by Medicare and female constituted lower proportion. Patients with HIV had higher LOS; however, the difference was not statically significant after adjusting for other confounders. Mortality rate was similar in both groups. Patients with history of HIV were more likely to develop pulmonary embolism, the difference was statistically significant even after adjusting for multiple confounders with OR of 6.43 (95% CI 3.76-11.02).

Discussion: The effect of HIV on IBD patients remains uncertain. This study showed that short term outcomes are largely similar between the 2 groups, however it appears that HIV increases the risk of pulmonary embolism significantly in CD patients. Further studies are needed to determine if additional venous thromboembolism / pulmonary embolism prophylaxis is needed in this patient cohort.


Disclosures:


Mohamed Ahmed, MD¹, Noor Hassan, MD², Khaled Elfert, MD³, Noor Mohamed, MD⁴, Ahmed Elkafrawy, MD⁵, Vinay Jahagirdar, MD², Francis A. Farraye, MD, MSc, MACG⁶, Hassan Ghoz, MD². P3530 - How Does Human Immunodeficiency Virus Affect Outcomes in Patients With Inflammatory Bowel Disease? An Analysis of the National Inpatient Sample Data From 2016 to 2020, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.