P3539 - Temporal Trends of Inflammatory Bowel Disease (IBD) Mortality in the United States from 1999 to 2020

Alexander Kusnik, MD¹, Sarath Lal Mannumbeth Renjithlal, MD¹, Rutwik Sharma, MD¹, Tausif Syed, MD^2
1Unity Hospital, Rochester, NY; ²Rochester General Hospital, Rochester, NY

Introduction: The global burden of inflammatory bowel diseases (IBD) is increasing, particularly in high-income countries. However, the literature presents conflicting evidence on changes in IBD incidence rates in North America over the past two decades. This study sought to examine IBD-related mortality utilizing the Centers for Disease Control and Prevention Wide database, with the aim of assessing whether any potential increase in incidence is also accompanied by changes in mortality over time.

Methods: A cross-sectional analysis was undertaken using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research database (CDC-WONDER) to examine the patterns of mortality linked to IBD, specifically identified by ICD codes - K50, K51, K52.9. This study aimed to determine age-adjusted mortality rates (AAMR) per 100,000 individuals and their corresponding annual percentage changes (APC), supported by 95% confidence intervals, through the application of Joinpoint regression analysis. Additionally, the study explored demographic and ethnic trends in relation to IBD mortality.

Results: From 1999 to 2020, a total of 41,915 deaths related to inflammatory bowel diseases (IBD) were recorded. Analyzing annual trends, the age-adjusted mortality rate (AAMR) exhibited a decline from 0.8 (95% CI 0.8-0.8) in 1999 to 0.3 (95% CI 0.3-0.3) in 2020. Over the entire period of 1999 to 2020, there was an overall decrease in the AAMR with an Annual Percentage Change (APC) of -4.3 (95% CI: -7.6 to -0.8, p ~0.019). Stratifying by sex, females displayed a higher AAMR of 0.6 (95% CI: 0.6-0.6), while males had an AAMR of 0.5 (95% CI: 0.5-0.5). Considering ethnicity, White individuals had the highest AAMR at 0.6 (95% CI: 0.6-0.6), followed by Black or African Americans at 0.5 (95% CI 0.5-0.4), American Indian or Alaskan Native at 0.4 (95% CI 0.3-0.4), and Asian or Pacific Islander at 0.2 (95% CI 0.1-0.2).

Discussion: From 1999 to 2020, an examination of mortality rates associated with inflammatory bowel diseases (IBD) in the United States using ICD codes reveals an overarching decline, aligning with findings from other investigations. This observed reduction in mortality signifies a favorable outcome for individuals affected by inflammatory bowel disease. This can potentially be ascribed to a variety of factors, including increased use of immunomodulatory medications, earlier implementation of biologics in the treatment process, and improvements in surgical interventions.


Disclosures:


Alexander Kusnik, MD¹, Sarath Lal Mannumbeth Renjithlal, MD¹, Rutwik Sharma, MD¹, Tausif Syed, MD². P3539 - Temporal Trends of Inflammatory Bowel Disease (IBD) Mortality in the United States from 1999 to 2020, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.