P3562 - Trends, Prevalence, and Outcomes of Ulcerative Colitis in Diabetes Mellitus: A Propensity Score Matching Analysis Study

Ese Uwagbale, MD¹, Olayemi Adeniran, MD², Zhanna Zavgorodneva, MD³, Samrah Siddiqui, MD², Chidiebele Omaliko, MD⁴, Rutwik Pradeep Sharma, MD⁵, Solomon Agbroko, MD⁶, Nida Khalid, MD¹, Dileepa Chathuranga, MD¹, Dasha Moza, MD¹, Karin Dunnigan, MD¹, Patrick Okolo, MD, MPH, FACG^1
1Rochester General Hospital, Rochester, NY; ²One Brooklyn Health, Brooklyn, NY; ³One Brookyln Health, Brooklyn, NY; ⁴One Brooklyn Health-Brookdale University Hospital Medical Center, Brooklyn, NY; ⁵Rochester Regional Health / Unity Hospital, Rochester, NY; ⁶Maimonides Medical Center, Brooklyn, NY

Introduction: Ulcerative colitis (UC) is a type of inflammatory bowel disease. Patients with UC often have other comorbidities, including diabetes mellitus (DM). However, there are very few studies on the effect of comorbid DM in patients with UC. This study aims to examine the clinical outcomes of hospitalized patients with UC and DM.

Methods: We analyzed the National Inpatient sample from January 1, 2016, to December 31, 2020. We conducted a retrospective study in patients with primary and secondary diagnoses of UC using the International Classification of Diseases, Tenth Revision (ICD-10-CM) codes. We had a total sample size of 116,496 patients with UC. The study population was further categorized into patients with comorbid DM, 23,837 patients, and those without DM (non-DM), 92,659 patients. The primary study outcomes were in-hospital mortality, UC-related complications, UC-related surgery, septicemia, Clostridium difficile infection, and colorectal cancer (CRC). The survey weighted annual trends in national estimates of UC and subgroups (DM and non-DM), demographics, and in-hospital mortality. Propensity score matching (PSM) was performed to control confounding factors.

Results: There was an increase in UC hospitalizations from 2016 to 2020, reflected among DM cohorts. After PSM, we obtained a well-balanced cohort of 23,628 DM matched to 23,628 non-DM groups, and the outcomes were compared. Patients in the DM group had an increased risk of sepsis/septicemia (17.2% vs. 14.3%, OR=1.24, CI: 1.18-1.31; p< 0.001) and depression (1.8% vs. 1.4%, OR=1.35, CI: 1.16-1.56; p< 0.001) than the non-DM groups. While the length of hospital stay was longer among the DM patients (3.7 (2.0 – 6.8) vs. 3.4 (1.8 – 6.3), OR=1.06, CI: 1.05-1.08; p < 0.01), the cost of hospitalization remained the same among the two cohorts. On the other hand, there was decreased risk of IBD-related complications among the DM patients (8.0% vs. 8.7%, OR=0.91, CI: 0.85-0.97; p< 0.004) compared to the non-DM cohorts. There was no difference in the risk of Clostridium difficile infection, CRC, and death among the two cohorts.

Discussion: Patients with Ulcerative colitis and diabetes have an increased rate of sepsis, septicemia, depression, and length of hospital stay, compared to patients with Ulcerative colitis without diabetes. The severity of Ulcerative colitis and diabetes was, however, not examined in this study. This study shows the extent to which diabetes affects the in-hospital outcomes of patients with Ulcerative colitis.



Disclosures:


Ese Uwagbale, MD¹, Olayemi Adeniran, MD², Zhanna Zavgorodneva, MD³, Samrah Siddiqui, MD², Chidiebele Omaliko, MD⁴, Rutwik Pradeep Sharma, MD⁵, Solomon Agbroko, MD⁶, Nida Khalid, MD¹, Dileepa Chathuranga, MD¹, Dasha Moza, MD¹, Karin Dunnigan, MD¹, Patrick Okolo, MD, MPH, FACG¹. P3562 - Trends, Prevalence, and Outcomes of Ulcerative Colitis in Diabetes Mellitus: A Propensity Score Matching Analysis Study, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.