P3596 - Correlation Between Intestinal Ultrasound and Fecal Calprotectin With Endoscopic Severity Scores (SES-CD, UCEIS) for Determining the Activity in Inflammatory Bowel Diseases

Award: Presidential Poster Award

Shishirendu S. Parihar, MBBS, MD¹, Aakash S. Shah, MBBS, MD², Devesh Yadav, MBBS, MD, DM², Ashish Verma, MBBS, MD¹, Vinod Kumar. Dixit, MBBS, MD, DM, FACG¹, Sunit K. Shukla, MBBS, MD, DM¹, Vinod Kumar, MBBS, MD, DM¹, Anurag Kumar. Tiwari, MBBS, MD, DM¹, Nitesh Bassi, MBBS, MD¹, Ishan Mittal, MBBS, MD¹, Vaibhav Karoliya, MBBS, MD^2
1Institute of Medical Sciences, Banaras Hindu Unviersity, Varanasi, Uttar Pradesh, India; ²Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Introduction: Disease activity assessment is crucial in inflammatory bowel diseases (IBD). However, invasive and expensive methods like endoscopy pose risks.^{1, 2} Faecal calprotectin (FC) and intestinal ultrasonography (IUS) are promising non-invasive indicators.^1-3 This study evaluated FC, IUS, and endoscopic severity scores (SES-CD and UCEIS) for disease activity assessment in IBD patients.

Methods: Prospective observational study, 49 IBD patients (UC=36, CD=13) underwent an endoscopy and IUS evaluation. Disease activity was assessed using SES-CD and UCEIS. FC was measured using an enzyme-linked immunosorbent assay. IUS examined five intestinal segments.

Results: Two hundred and forty-five segments were analyzed, with a majority of females (53.1%). Medication history: steroids (85.7%), 5-aminosalicylic acid (44.9%), azathioprine (30.6%), biologics (12.2%). Common UC location: left side (47.2%), extensive UC (27.8%), ulcerative proctitis (25%). Common CD locations: ileum (46.1%), ileocolonic (30.8%), colonic (23.1%). Bowel wall thickness varied across segments. Vascularity and stratification varied. Mean UCEIS and SES-CD scores indicated disease severity. Positive correlations were found between FC and SES-CD (r=0.690, p=0.009) and UCEIS (r=0.333, p=0.045).

Discussion: Positive correlations were observed between FC, IUS, and endoscopic severity scores in CD and UC patients. Higher scores and FC levels are associated with increased disease activity and mucosal inflammation on IUS. FC and IUS provide non-invasive alternatives to endoscopy, enhancing disease assessment and treatment decisions. Combining FC and IUS may improve assessment by capturing both inflammatory and structural abnormalities. To conclude, FC, IUS, and endoscopic severity scores correlate significantly in IBD patients. They offer non-invasive indicators for disease activity assessment, treatment decisions, and monitoring. These alternatives are convenient and cost-effective for evaluating IBD disease activity.


Disclosures:


Shishirendu S. Parihar, MBBS, MD¹, Aakash S. Shah, MBBS, MD², Devesh Yadav, MBBS, MD, DM², Ashish Verma, MBBS, MD¹, Vinod Kumar. Dixit, MBBS, MD, DM, FACG¹, Sunit K. Shukla, MBBS, MD, DM¹, Vinod Kumar, MBBS, MD, DM¹, Anurag Kumar. Tiwari, MBBS, MD, DM¹, Nitesh Bassi, MBBS, MD¹, Ishan Mittal, MBBS, MD¹, Vaibhav Karoliya, MBBS, MD². P3596 - Correlation Between Intestinal Ultrasound and Fecal Calprotectin With Endoscopic Severity Scores (SES-CD, UCEIS) for Determining the Activity in Inflammatory Bowel Diseases, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.