P3643 - Incidence, Disability-Adjusted Life Year, and Mortality of Inflammatory Bowel Disease in Southeast Asia and Western Pacific Regions from 2000 to 2019

Aunchalee Jaroenlapnopparat, MD¹, Pojsakorn Danpanichkul, MD², Kinnari Kher, MD^3
1Mount Auburn Hospital/Harvard Medical School, Cambridge, MA; ²Chiang Mai University, Mueang Chiang Mai, Chiang Mai, Thailand; ³Mount Auburn Hospital, Cambridge, MA

Introduction: The incidence of inflammatory bowel disease (IBD) has progressively increased in the newly industrialized countries in Asia. However, the epidemiology data in Asia are sparse. We aimed to study the epidemiology trend of IBD in South East Asia (SEA) and West Pacific (WP).

Methods: This study analyzed the incidence, disability-adjusted life years (DALYs), and mortality for IBD in the SEA and WP regions between 2000 and 2019 from the Global Burden Disease (GBD) Study 2019. Raw numbers of cases, age-standardized rate, and genders were extracted from the study. Joinpoint program was used to analyze the annual percentage change (APC).

Results: Between 2000 and 2019, the overall incidence of IBD had increased significantly in WP but not in SEA. There was a higher increase among females in both the WP and SEA regions. Overall mortality rates of IBD in WP had decreased significantly with improvement of mortality in females more than males (APC -4.71% in females vs -3.20% in males). Similarly, overall mortality of IBD in SEA had decreased significantly, but with males achieving better improvement of mortality than females (APC -1.99% in females vs -2.13% in males). DALYs due to IBD in WP decreased significantly, with better improvement in females than males. Statistically significant decrease of DALYs due to IBD in SEA was similarly observed, where males had achieved a better improvement of DALYs than females.

Discussion: Between 2000 and 2019, there was a greater increased incidence of IBD in WP compared to SEA, especially in females. This may reflect westernized lifestyles or improvement of IBD diagnosis. Mortality rates and DALYs in both WP and SEA were significantly lower, with better improvement in females in WP compared to better improvement in males in SEA. The mortality and DALYs were decreased in both regions which could reflect better IBD care.



Disclosures:


Aunchalee Jaroenlapnopparat, MD¹, Pojsakorn Danpanichkul, MD², Kinnari Kher, MD³. P3643 - Incidence, Disability-Adjusted Life Year, and Mortality of Inflammatory Bowel Disease in Southeast Asia and Western Pacific Regions from 2000 to 2019, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.