P1437 - Aspirin Use and Its Association With Severity and Complications of Acute Pancreatitis

Praneeth Bandaru, MD¹, Arnold Forlemu, MD¹, Vijay Gayam, MD¹, Vishnu Poojitha Ronda, MBBS, MD², Enmanuel Then, ³, Pavani Reddy Garlapati, MD¹, Vikash Kumar, MD¹, Raissa Nana Sede Mbakop, MD⁴, Saigopal R. Gujjula, ⁵, Denzil Etienne, MD¹, Madhavi Reddy, MD^1
1Brooklyn Hospital Center, Brooklyn, NY; ²Mahatma Gandhi Medical College and Research Institute, Pondicherry, India, Brooklyn, NY; ³Universidad Iberoamericana, Gazcue, Distrito Nacional, Dominican Republic; ⁴Piedmont Athens Regional Medical Center, Athens, GA; ⁵American University of Antigua, Coolidge, Saint John, Antigua and Barbuda

Introduction: Acute pancreatitis is one of the major gastrointestinal causes of hospitalization, significant user of health care costs and is widely agreed that severity of acute pancreatitis plays a major role in the outcomes of acute pancreatitis. Aspirin has been traditionally used for its anti-platelet and anti-inflammatory action. Prior animal studies have demonstrated beneficial effects of aspirin usage in acute pancreatitis, possibly because of its anti-inflammatory effect on preventing the complications of acute pancreatitis including pancreatic necrosis, ARDS etc. These findings have not been studied in humans so far. In this study we aim to study the association between aspirin usage and severity, complications of acute pancreatitis in patients admitted to hospital in United States.

Methods: We conducted a nationwide review from 2016 to 2017 using the National Inpatient Sample (NIS) data. Patients ≥ 18 years old with acute pancreatitis (uncomplicated and complicated) were identified using the ICD-10-CM codes. Among these patients, 15,495 of them were taking aspirin. Adjusted odds ratio (OR) and confidence intervals (CI) at 99% were reported.

Results: The number of patients with acute pancreatitis was 180,610, with a mean age of 53 years with 51.9% males. Aspirin use was associated with a lower risk for acute pancreatitis (OR 0.70, 0.69-0.71). Compared to aspirin non users, aspirin users were less likely to have severe or complicated acute pancreatitis (uncomplicated pancreatitis rates- 63.4% vs 59.5%, p< 0.001), less likely to have uninfected and infected necrotizing pancreatitis (1.5% vs 1.7% and 0.5% vs 0.6% respectively, p< 0.001), less likely to develop pseudocyst (3.6% vs 5.4%, p< 0.001), less likely to have ARDS (0.2% vs 0.3%, p< 0.001), and less likely to be mechanically ventilated (2.4% vs 4.1%, p< 0.001) (Table 1). However, aspirin users were more likely to develop AKI than non-users (21.5% vs 16.9%, p< 0.001). On Multivariate analysis, Black, Hispanic, Asian, and Native American aspirin users with acute pancreatitis were more likely to have AKI compared to whites.

Discussion: This study results have suggested that aspirin usage is associated with significantly lower risk of complications and organ failure except for AKI in patients with acute pancreatitis. These findings were proven in prior animal studies, however well-designed human studies are lacking, which open doors for more research, and can potentially affect the morbidity and mortality associated with acute pancreatitis.


Disclosures:


Praneeth Bandaru, MD¹, Arnold Forlemu, MD¹, Vijay Gayam, MD¹, Vishnu Poojitha Ronda, MBBS, MD², Enmanuel Then, ³, Pavani Reddy Garlapati, MD¹, Vikash Kumar, MD¹, Raissa Nana Sede Mbakop, MD⁴, Saigopal R. Gujjula, ⁵, Denzil Etienne, MD¹, Madhavi Reddy, MD¹. P1437 - Aspirin Use and Its Association With Severity and Complications of Acute Pancreatitis, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.