Mohammad Aldiabat, MD1, Tabeer Rana, DO2, Yassine Kilani, MD3, Saba Altarawneh, MD4, Aarushi Sudan, MD5, Iqra Arshad, MD3, Yazan Aljabiri, MBBS6, Laith Alhuneafat, MD2 1NYU Langone, New York, NY; 2Allegheny Health Network, Pittsburgh, PA; 3Lincoln Medical Center, New York, NY; 4Marshall University, Huntington, WV; 5Jacobi Medical Center, New York, NY; 6NYC Health + Hospitals/Lincoln, Bronx, NY
Introduction: We aim to investigate the determinants and risk factors of developing acute pancreatitis (AP) in COVID-19 patients. Secondarily, we aim to evaluate how inpatient outcomes in those with AP compare to COVID-19 patients without AP.
Methods: This is an observational analysis of the National Inpatient Sample of the year 2020. Adult patients who were admitted with a diagnosis of COVID-19 were included and stratified by the development of AP during their hospitalization. Multivariate logistic analysis was performed while adjusting for age, sex, race and Charlson Comorbidity Index (CCI) to assess predictors for the development of AP and inpatient outcomes between both groups. Data was considered statistically significant if p-value was < 0.05.
Results: Factors associated with higher risk of AP included Hispanic ethnicity, higher CCI score, history of chronic kidney disease, chronic liver disease, malnutrition, portal hypertension and alcohol use. COVID-19 patients who developed acute pancreatitis were at higher risk of mortality, acute coronary syndrome, acute kidney injury, sepsis, septic shock, in-hospital cardiac arrest, invasive mechanical ventilation, upper gastrointestinal bleeding, prolonged length of stay and increased cost of care.
Discussion: Acute pancreatitis is associated with higher mortality and morbidity in hospitalized COVID-19 patients. Hispanic ethnicity, higher CCI score, history of chronic kidney disease, chronic liver disease, malnutrition, portal hypertension and alcohol use is associated with higher risk of developing AP in hospitalized COVID-19 patients.
Figure: Figure 1: Forest Plot of Hospitalization Outcomes in Admitted COVID-19 Patients with AP, Compared to Admitted COVID-19 Patients without AP
Disclosures:
Mohammad Aldiabat indicated no relevant financial relationships.
Tabeer Rana indicated no relevant financial relationships.
Yassine Kilani indicated no relevant financial relationships.
Saba Altarawneh indicated no relevant financial relationships.
Aarushi Sudan indicated no relevant financial relationships.
Iqra Arshad indicated no relevant financial relationships.
Yazan Aljabiri indicated no relevant financial relationships.
Laith Alhuneafat indicated no relevant financial relationships.
Mohammad Aldiabat, MD1, Tabeer Rana, DO2, Yassine Kilani, MD3, Saba Altarawneh, MD4, Aarushi Sudan, MD5, Iqra Arshad, MD3, Yazan Aljabiri, MBBS6, Laith Alhuneafat, MD2. P1462 - Determinants and Outcomes of Acute Pancreatitis in Patients Hospitalized for COVID-19: Insights From the National Inpatient Sample, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.
