P1466 - Prospective Evaluation of Sexual Dysfunction in Men with Chronic Pancreatitis: A Pilot Study

Ishani Shah, MD¹, Awais Ahmed, MD², Kelsey Anderson, MD², Rachel Bocchino, MD³, Shaharyar Zuberi, MD², Steven Freedman, MD, PhD², Robert Carrasquillo, MD⁴, Sunil G. Sheth, MD^2
1University of Utah School of Medicine, Salt Lake City, UT; ²Beth Israel Deaconess Medical Center, Boston, MA; ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; ⁴Lahey Hospital and Medical Center, Burlington, MA

Introduction: Chronic pancreatitis (CP) is associated with chronic pain and poor quality of life (QOL). While other QOL parameters in CP (anxiety, depression, sleep disturbances) have been described, sexual dysfunction (SD) in CP has not been studied. Therefore, we aimed to study the prevalence of SD and its association with QOL in men with CP.

Methods: Male patients with CP were prospectively enrolled in the outpatient Pancreas Clinic of our tertiary care hospital from 2021-2022. Patients with known SD or taking medications for SD were excluded. Enrolled patients filled 4 validated questionnaires: International Index of Erectile Function-5 (IIEF-15), erectile hardness score (EHS), pancreatitis quality of life instrument (PANQOLI) and short form survey (SF-12). The completed IIEF-15 and EHS questionnaires were scored by a blinded expert urologist, who categorized patients as having absent, minimal, moderate and severe SD. Completed PANQOLI and SF-12 questionnaires were also reviewed and mean scores were obtained. We then compared CP patients with and without SD. Patients diagnosed with SD based on questionnaires were also offered laboratory workup and evaluation in the urology clinic (results pending for second part of the study).

Results: Thirty patients were enrolled in the study. Of these, SD was present in 18 patients (mild in 9, moderate in 1 and severe in 8 patients) based on review of the IIEF-5 and EHS questionnaires. The average age of patients with SD was 55.7 years (±10.5), average CCI was 2.95 (±1.99), and average BMI was 28.6 kg/m² (±59.3). Majority patients were White (62%). They had been followed in our Pancreas Center longitudinally for an average of 7.42 years (±5.56). The most common etiology of CP was alcohol (31.6%) in these patients; 21% were former and 26.3% were active smokers. No significant differences were noted in clinical characteristics or QOL metrics between the 2 groups, except for a non-significant increase in diabetes in CP patients with SD (73.7% vs 45.5%) (Table 1).

Discussion: This is a unique pilot study showing that SD is present in 60% of males with CP. No difference was noted in the QOL of CP patients with and without SD, albeit limited by our small sample size. With the focus of CP care shifting towards comprehensive symptom control and QOL improvement, physicians caring for CP patients should routinely inquire for symptoms of SD and offer a urology referral if indicated.


Disclosures:


Ishani Shah, MD¹, Awais Ahmed, MD², Kelsey Anderson, MD², Rachel Bocchino, MD³, Shaharyar Zuberi, MD², Steven Freedman, MD, PhD², Robert Carrasquillo, MD⁴, Sunil G. Sheth, MD². P1466 - Prospective Evaluation of Sexual Dysfunction in Men with Chronic Pancreatitis: A Pilot Study, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.