P1620 - Burden of Cytomegalovirus Colitis in Hospitalizations for Inflammatory Bowel Disease: Analysis from National Inpatient Sample Database

Sania Saleem, MD¹, Daksh Ahluwalia, MD¹, Saira Saleem, MBBS², Muhammad Bilal Ibrahim, MD¹, Ayusha Poudel, MD³, Benjamin Go, MD^1
1John H. Stroger, Jr. Hospital of Cook County, Chicago, IL; ²Mayo Hospital, Lahore, Lahore, Punjab, Pakistan; ³CCH, Chicago, IL

Introduction: Cytomegalovirus colitis (CMV Colitis) is predominantly a disease of the immunocompromised and has been known to affect patients with inflammatory bowel disease (IBD). Multiple factors, including altered immune system, disrupted mucosal barrier, and use of immunomodulators, predispose patients with IBD to CMV disease. We aim to analyze the incidence of CMV Colitis in patients hospitalized with IBD and its impact on hospital outcomes.

Methods: National Inpatient Sample Database from 2016-2020 was queried to identify hospitalizations with IBD using ICD-10 codes. These hospitalizations were determined to have CMV Colitis if they had undergone colonoscopy during the hospital stay and had a diagnosis of CMV Infection. Stata-17 was used to run Multivariate Linear and Logistic regression analysis to determine the odds.

Results: Of the total number of hospitalizations for IBD 911800, 1650 had CMV Colitis. CMV colitis hospitalizations had six times higher odds of mortality aOR 6.98 (P < 0.01). CMV Colitis hospitalizations had a higher average length of stay (LOS) by ten days P< 0.001 and had a higher Total Hospital Charge (THC) of 86,325 USD. CMV Colitis IBD hospitalizations had higher odds of sepsis (aOR: 5.02 P< 0.001), Acute Respiratory Failure (aOR: 4.27 P< 0.001), and blood transfusion (aOR: 3.41 P< 0.001).

No statistically significant difference was found in odds for mechanical ventilation, vasopressor requirement, Acute Kidney Injury, Colectomy, Bowel Perforation, or Peritonitis.

Discussion: Our study shows that CMV colitis in IBD patients is associated with increased odds of mortality. CMV also significantly increases morbidity with higher odds of sepsis, respiratory failure, mechanical ventilation, and blood transfusions. Hence, it leads to a more significant economic burden (higher LOS and THC). CMV colitis did not increase the odds of colitis-related complications, including peritonitis, bowel perforation, or odds of colectomy.


Disclosures:


Sania Saleem, MD¹, Daksh Ahluwalia, MD¹, Saira Saleem, MBBS², Muhammad Bilal Ibrahim, MD¹, Ayusha Poudel, MD³, Benjamin Go, MD¹. P1620 - Burden of Cytomegalovirus Colitis in Hospitalizations for Inflammatory Bowel Disease: Analysis from National Inpatient Sample Database, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.