P1764 - Association Between Physical Activity and the Risk of Colorectal Cancer Among Individuals With Types II Diabetes

Yanjun Wu, MD¹, Meijun Meng, MD¹, Felix W. Leung, MD², Chongyang Duan, PhD³, Weihong Sha, PhD⁴, Hao Chen, PhD^4
1Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China; ²University of California Los Angeles, Los Angeles, CA; ³Southern Medical University, Guangzhou, Guangdong, China; ⁴Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China

Introduction: Several epidemiological studies have identified type II diabetes (T2D) as one of the risk factors for CRC. Given the established associations between T2D and increased risks of CRC, more attention need to be devoted to identifying modifiable measures for cancer prevention in the daily management of T2D. In recent years, physical activity (PA) has been shown to have some protective effects against a variety of chronic diseases, including but not limited to cancer. However, the relationship between PA and CRC development in people with T2D is currently unclear. To bridge the knowledge gap, we investigated the relationship of PA with the risk of CRC using a large population-based cohort database.

Methods: Participants from the UK Biobank, aged 38-73 years with complete information on PA and CRC outcomes were included. PA was collected by questionnaire and categorised as low (< 600 metabolic equivalent (MET)-min/week), moderate (600 to < 3000 MET-min/week), and high (≥ 3000 MET-min/week). Hazard ratios (HR) and 95% confidence intervals (CI) for CRC outcome among individuals with T2D were calculated using the COX proportional hazards regression. Furthermore, polygenic risk scores (PRS) summarizing from UK Biobank were categorized into three genetic risk levels: low, intermediate, and high, which were further evaluated as subgroup analyses with multivariable-adjusted models.

Results: 33,290 individuals had a median follow-up of 13.59 (IQR 12.95-13.34) years. For individuals with T2D, compared to low PA, the multivariate adjusted HR for CRC was 0.81 (0.67-0.99) and 0.73 (0.58-0.92) in moderate and high PA groups, respectively (Table). However, while no significant association was found between PA and CRC in total population from UK Biobank. A higher PRS was related to increased risks of CRC. Moreover, when stratified by PRS, moderate (HR, 0.70; 95% CI, 0.50-0.98) and high (HR, 0.51; 95% CI, 0.33-0.79) PA were associated with CRC in the higher PRS group in T2D participants. Additionally, T2D participants with both a low PRS and high PA had the lowest risk of CRC (HR, 0.24; 95% CI, 0.13-0.44).

Discussion: Increased PA in individuals with T2D showed a suggestive positive relation with risk of CRC. These findings further support the substantial benefit of consistent moderate to high physical activity in reducing the subsequent burden of CRC and reinforce the importance of promoting consistent moderate to high physical activity in CRC treatment and prevention in T2D patients.


Disclosures:


Yanjun Wu, MD¹, Meijun Meng, MD¹, Felix W. Leung, MD², Chongyang Duan, PhD³, Weihong Sha, PhD⁴, Hao Chen, PhD⁴. P1764 - Association Between Physical Activity and the Risk of Colorectal Cancer Among Individuals With Types II Diabetes, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.