P0030 - Outcomes of Acute Pancreatitis in Patients With a History of Solid Organ Transplantation

Ravi Teja Pasam, MBBS, MPH¹, Srilekha Chava, MBBS², Karim T.. Osman, MD^3
1Wentworth-Douglass Hospital, Portsmouth, NH; ²Portsmouth, NH; ³Lahey Clinic, Burlington, MA

Introduction: Acute pancreatitis is a well known entity that has been extensively studied. But there is limited data with regard to pancreatitis in patients with a history of solid organ transplantation (SOT). The objective of our study was to assess the outcomes of acute pancreatitis in patients with a history of SOT.

Methods: The National Inpatient Sample (NIS) database from 2016 was used for this study. Patients with age less than 18 years or those without a diagnosis of acute pancreatitis were excluded. The exposure variable was a history of SOT (kidney, heart, lung, liver or intestinal transplantation). Mortality was the primary outcome. Length of stay in the hospital and total charges for the hospitalization were the secondary outcomes. Categorical and continuous outcomes were analyzed with logistic regression and linear regression respectively. Statistical Analysis System (SAS) was used to analyze the data.

Results: A total of 90,796 patient encounters for acute pancreatitis were included, of which 130 had a history of SOT. Mean age was 53.34 years and 48.34% were females. There was no significant difference in mortality between patients with and without a history of SOT (p-value: 0.53). Length of stay was significantly higher for patients with SOT compared to those without SOT (7.33 days vs 5.45 days; p-value: 0.006). On multiple regression analysis, history of SOT was associated with an increase in LOS by 1.43 days (p-values 0.03) (Table 1). Other factors associated with LOS along with SOT on multiple regression analysis were age, female sex, race, smoking, obesity, treatment at a teaching hospital, patients transferred in from another hospital, and admission on a weekend. This longer length of stay translated into higher mean total charges for the hospital stay as well ($187, 936 vs $55, 251, p-value: 0.009).

Discussion: Although a history of SOT was not associated with higher mortality due to acute pancreatitis, it was associated with a significantly longer length of stay in the hospital and total charges for the hospitalization for acute pancreatitis. Further research into factors contributing to the longer stay is warranted to identify areas of improvement.



Disclosures:


Ravi Teja Pasam, MBBS, MPH¹, Srilekha Chava, MBBS², Karim T.. Osman, MD³. P0030 - Outcomes of Acute Pancreatitis in Patients With a History of Solid Organ Transplantation, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.