P0177 - Gender Differences in Lower Gastrointestinal Malignancies Outcomes in a Developing Middle Eastern Country Over 18 Years

Ahmed A. Abdulelah, MD¹, Zaid A. Abdulelah, MD², Abdulrahman Alhajahjeh, ³, Ahmad Ghazzawi, MD¹, Dalya Murshedi, MD¹, Amer Khatib, MD^1
1School of Medicine, The University of Jordan, Amman, 'Amman, Jordan; ²St Bartholomew's Hospital, London, England, United Kingdom; ³University of Jordan School of Medicine, Amman, 'Amman, Jordan

Introduction: Lower gastrointestinal (LGI) malignancies impose significant global health burden due to the associated morbidity and mortality. More importantly, there are significant gender differences and disparities globally in the overall survival and outcomes in LGI malignancies and therefore evaluation of epidemiological differences of LGI cancers, particularly in the Middle East where very scarce findings are available, is paramount for the introduction of effective interventions, both therapeutic and preventative.

Methods: Comprehensive data on 12641 individuals of different nationalities residing in Jordan who were diagnosed with LGI cancers (colorectal and anal cancer) during the period 2000-2018 was retrieved from the Jordan Cancer Registry. Epidemiological analysis was performed for males and females separately, to evaluate for any gender disparities in outcomes in the Middle East.

Results: Regarding colorectal cancer, a total of 6914 males with a mean age of 59 ± 13.5 years old and 5503 females with a mean age of 56.6 ± 13.4 years old were included in the analysis. Moderately differentiated tumors were the most common in both, and the portion of patients presenting with distant metastasis was virtually identical (17.4% for males and 17.7% for females). Males and females had a comparable, but slightly better in females, overall survival rates as the overall rates for females were 86.8% and 76.3% at 1-year and 5-year interval, respectively. On the contrary, the overall rates for males were 85.8% and 74.2% at 1-year and 5-year interval, respectively. A statistically significant increase in the crude incidence of colorectal cancer in both males and females was evident with an estimated effect of 0.320 (p-value< 0.001). In terms of anal cancer, 132 males with a mean age of 57.5 ± 12.9 years old and 92 females with a mean age of 56.8 ± 15.1 years old were included. Males and females had a similar overall survival rates with the overall rates in females being 95.7% and 88.0% at 1-year and 5-year interval, respectively. Whereas the overall rates in males were 95.5% and 88.6% at 1-year and 5-year, respectively. There was a statistically insignificant increase in the crude incidence of anal cancer over 18 years in both males and females with an estimated effect of 0.001.

Discussion: Over 18 years, LGI malignancies in Jordan demonstrated a better overall survival in females in terms of colorectal cancer, and virtually similar rates to males in regard to anal cancer.


Disclosures:


Ahmed A. Abdulelah, MD¹, Zaid A. Abdulelah, MD², Abdulrahman Alhajahjeh, ³, Ahmad Ghazzawi, MD¹, Dalya Murshedi, MD¹, Amer Khatib, MD¹. P0177 - Gender Differences in Lower Gastrointestinal Malignancies Outcomes in a Developing Middle Eastern Country Over 18 Years, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.