P0345 - The Incidence Rate of Colorectal Cancer in the Adult US Population - Should We Further Decrease the Age of Colorectal Cancer Screening?

Calvin Ghimire, MD¹, Sajan Acharya, MD², Manasik Abdu, MD³, Pradip Chaudhary, MD⁴, Bibek Karki, MD⁴, Matthew Jankowski, MD¹, Dheeraj Alexander, MD⁵, Alexander Rabadi, MD⁵, Sajana Poudel, MD⁶, Sushila Adhikari, DR⁷, Manoj Ghimire, MD⁸, Pujan Kandel, MD⁹, Arvind Kunadi, MD⁵, Abdalla Adil, MD^5
1Michigan State University/McLaren Flint Hospital, Flint, MI; ²New York Medical College, New York, NY; ³University at Buffalo-Catholic Health System, Buffalo, NY; ⁴Hurley Medical Center, Flint, MI; ⁵McLaren Flint Hospital, Flint, MI; ⁶John H. Stroger, Jr. Hospital of Cook County, Chicago, IL; ⁷University of Punjab, University College of Pharmacy, Lahore, Punjab, Pakistan; ⁸Mayo Clinic Florida, Jacksonville, FL; ⁹Mayo Clinic, Jacksonville, FL

Introduction: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Colonoscopy is the gold standard for screening for CRC. Multiple societies widely accepted screening colonoscopy starting age 50 in their guidelines since 1996. Current literature has revealed an increasing trend in CRC among younger age groups, resulting in a lowering of the CRC screening age to 45. We determined whether lowering the screening age even further is beneficial by examining the incidence of CRC in adults younger than 50.

Methods: We used Incidence - SEER Research Limited-Field Data, 22 Registries, Nov 2021 Sub (2000-2019) which was released in April 2022, based on the November 2021 submission for the calculation of incidence rates of CRC. SEER 22 covers approximately 47.9% of the U.S. population (based on the 2010 census). SEER*Stat 8.4.1 was used to obtain age-adjusted rates for different age-group. We used Join point software, version 4.9.1.0 by National Cancer Institute, annually to create log-linear time trends.

Results: We identified total 137,875 diagnosed cases of CRC. The total cases of CRC among 20-24 years, 25-29 years, 30-34 years, 35-39 years, and 40-44 years and 45-49 years were 2,573, 5,244, 10,304, 19,366, 36,001 and 64,387 respectively. The trend of CRC among 20-24 years, 25-29 years, 30-34 years, 35-39 years, and 40-44 years increased at 6.7%* (95% CI (confidence interval), 5.5 to 7.9, P < 0.001), 3.6%* (95% CI, 3.2 to 4.1, P < 0.001), 2.9%* (95% CI, 2.4 to 3.3, P < 0.001), 2.3%* (95% CI, 2.1 to 2.6, P < 0.001), 1.9%* (95% CI, 1.7 to 2.1, P < 0.001) annually respectively. However, for the age group 45-49 years, the incidence rate of CRC increased from 2000 to 2012 at 0.7%* (95% CI, 0.3 to 1, P =0.001), and increased further at a higher rate of 2.2%* (95% CI, 1.4 to 2.9, P < 0.001) annually.

Discussion: Our study revealed an increasing trend of CRC in the US adult population across all age groups from the year 2000 to 2019. However, incidence rates were significantly higher among the age group 45-49 years, followed by 40-45 years with the uptrend. Lowering the screening age for CRC will certainly be beneficial in the age group 40-45 years, but should consider healthcare costs.



Disclosures:


Calvin Ghimire, MD¹, Sajan Acharya, MD², Manasik Abdu, MD³, Pradip Chaudhary, MD⁴, Bibek Karki, MD⁴, Matthew Jankowski, MD¹, Dheeraj Alexander, MD⁵, Alexander Rabadi, MD⁵, Sajana Poudel, MD⁶, Sushila Adhikari, DR⁷, Manoj Ghimire, MD⁸, Pujan Kandel, MD⁹, Arvind Kunadi, MD⁵, Abdalla Adil, MD⁵. P0345 - The Incidence Rate of Colorectal Cancer in the Adult US Population - Should We Further Decrease the Age of Colorectal Cancer Screening?, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.