P0408 - Comparative Trends of Gender-Based Disparities in Patients With Barrett's Esophagus: A 10-Year National Cohort Study

Karina Fatakhova, MD¹, Benjamin Glazebnik, ², Pratik Patel, MD³, Hassam Ali, MD⁴, Lindsey Donnelly, MD¹, Faisal Inayat, MBBS⁵, Rubaid Dhillon, MD⁶, Glazer Emily, MD^1
1Mather Hospital/Northwell Health, Port Jefferson, NY; ²Vassar College, Poughkeepsie, NY; ³Mather Hospital/Hofstra University Zucker School of Medicine, Port Jefferson, NY; ⁴ECU Health Medical Center / Brody School of Medicine, Greenville, NC; ⁵Allama Iqbal Medical College, Lahore, Punjab, Pakistan; ⁶Cleveland Clinic, Cleveland, OH

Introduction: Barrett’s esophagus (BE) is a precursor lesion of esophageal adenocarcinoma (EAC) that is a complication of chronic gastroesophageal reflux (GERD). BE is diagnosed via pathology with characteristic findings of metaplastic change of the typical esophageal squamous epithelium to specialized columnar epithelium. Given the increasing rates of BE and EAC, multiple organizations have developed guidelines regarding the diagnosis and management of BE. While these guidelines all include the male sex as a risk factor for the development of BE and EAC, the question remains whether certain risk factors should qualify females for screening endoscopy.

Methods: We conducted a retrospective study using the National Inpatient Sample (NIS) database, to identify patients with a diagnosis of Barrett's esophagus from January 1, 2009 to December 31, 2019.

Results: There were 486,751 (40.4%) hospitalizations with a diagnosis of BE in females for the study period. The mean age was higher in females than in males with BE. Females had a higher frequency of GERD than males (57% vs. 51%) (P = 0.0035) with trend analysis revealing increasing GERD from 50% in 2009 to 64% in 2019 (P < 0.001) . Females had a higher frequency of obesity than males (17% vs. 13%) (P < 0.001) with rising trends from 12% in 2009 to 22% in 2019 (P < 0.001). Females had a lower prevalence of smoking than males (23% vs. 33%) (P < 0.001); however, trend analysis among females revealed the rising prevalence of smoking from 13% in 2009 to 31% in 2019 (P < 0.001). Trend analysis among females with BE revealed the rising prevalence of alcohol abuse and esophageal adenocarcinoma and the decreasing prevalence of H.Pylori and diabetes (P < 0.001). Adjusted linear regression revealed a significantly higher LOS in female patients compared to males for BE hospitalizations (4.7 vs. 5.03 days, P < 0.001) for the study period. The MIC increased from $35,135 in 2009 to $60,333 in 2019 for female hospitalizations with BE (P < 0.001).

Discussion: According to the results of our study, the prevalence of BE amongst females has steadily risen from 2009-2019. The rate of female admissions with the diagnosis of BE in 2019 is similar to the rate of male admissions with the diagnosis of BE in 2009. Furthermore, 40% of total hospitalizations with the diagnosis of BE from 2009-2019 were that of females. While males have traditionally warranted greater awareness for the development of BE, the data suggests that the risk in females is not insignificant.



Disclosures:


Karina Fatakhova, MD¹, Benjamin Glazebnik, ², Pratik Patel, MD³, Hassam Ali, MD⁴, Lindsey Donnelly, MD¹, Faisal Inayat, MBBS⁵, Rubaid Dhillon, MD⁶, Glazer Emily, MD¹. P0408 - Comparative Trends of Gender-Based Disparities in Patients With Barrett's Esophagus: A 10-Year National Cohort Study, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.