P0523 - Prevalence of Depression Is Higher in Irritable Bowel Syndrome Compared to Chronic GI and Non-GI Disorders

Sunday, October 22, 2023

3:30 PM – 7:00 PM PT

Location: Exhibit Hall

Has Audio

Presenting Author(s)

AN

Ahmad Nawaz, MD

Yale University School of Medicine
New Haven, CT

Ahmad Nawaz, MD¹, Abdelkader Chaar, MD¹, Rabia Rizwan, MD¹, Shanti Patel, MD¹, Badr Al-Bawardy, MD²
¹Yale University School of Medicine, New Haven, CT; ²King Faisal Specialist Hospital and Research Center, Riyadh, Ar Riyad, Saudi Arabia

Introduction: Irritable bowel syndrome (IBS) is a chronic multifactorial gastrointestinal condition that substantially affects the quality of life. IBS has been associated with a high prevalence of psychological disorders including depression. In this study, we investigated the prevalence of depression IBS compared to chronic GI and non-GI disorders.

Methods: We utilized the national inpatient sample (2018- 2019) to calculate the rate of depression among adult pts with a history of IBS and different chronic disorders. ICD-10 codes were used to identify pts with history of IBS, depression, and different chronic conditions. Using multivariate logistic regression, we assessed the odds of having a co-diagnosis of depression in IBS pts compared to other chronic disorders commonly associated with depression. We also assessed odds of having a co-diagnosis of depression in IBS pts compared to other chronic disorders after excluding pts with co-diagnosis of fibromyalgia, chronic pain syndrome and/or anxiety.

Results: The analysis included 632,570 pts with a diagnosis of IBS; 29.86% of them had a co-diagnosis of depression. IBS pts who had co-diagnosis of depression were mostly females (84.7%) and mean age was 60.48 +/- 17.34 years. The prevalence of depression in the general population without IBS was 14.05%. IBS pts had more than double the chances of having a diagnosis of depression when compared to the general population (OR 2.23, 95% CI 2.19-2.26; p< 0.001). When compared to other chronic disorders, IBS pts had higher odds of having depression than those with congestive heart failure (OR 1.72, 95% CI 1.68-1.75; p< 0.001), chronic ischemic heart disease (OR 1.59, 95% CI 1.56-1.62; p< 0.001), diabetes (OR 1.64, 95% CI 1.61-1.66; p< 0.001), end-stage kidney disease on dialysis (OR 1.98, 95% CI 1.93-2.03; p< 0.001), HIV (OR 1.46, 95% CI 1.40-1.52; p< 0.001), IBD (OR 1.74, 95% CI 1.70-1.78; p< 0.001), leukemia (OR 2.22, 95% CI 2.14-2.29; p< 0.001), metastatic cancer (OR 1.49, 95% CI 1.42-1.55; p< 0.001), multiple sclerosis (OR 1.17, 95% CI 1.14-1.20; p< 0.001) and osteoarthritis ((OR 1.28, 95% CI 1.25-1.30; p< 0.001). After excluding pts with co-diagnosis of fibromyalgia, anxiety and chronic pain syndrome, IBS pts still had higher odds of having depression as compared to other chronic diseases (except for alcohol-related disorders and MS).

Discussion: The prevalence of depression in IBS is high compared to other chronic medical disorders. Depression symptomatology should be systematically checked in IBS pts.

Depression rates among patients with IBS and different chronic conditions
Population	Prevalence of depression	Adjusted Odds Ratio^#* [Risk of depression in IBS compared to different chronic conditions]	95% CI	p-value
IBS	29.86%	--	--	--
Congestive heart failure	13.99%	1.72	1.68 - 1.75	< 0.001
Chronic ischemic heart disease	14.33%	1.59	1.56 - 1.62	< 0.001
Diabetes	15.38%	1.64	1.61 - 1.66	< 0.001
End-stage kidney disease on dialysis	12.90%	1.98	1.93 -2.03	< 0.001
Inflammatory bowel disease	18.15%	1.74	1.70 - 1.78	< 0.001
Osteoarthritis	19.27%	1.28	1.25 - 1.30	< 0.001
HIV	17.49%	1.46	1.40 - 1.52	< 0.001
Leukemia	13.29%	2.22	2.14 - 2.29	< 0.001
Lymphoma	12.38%	2.42	2.35 - 2.50	< 0.001
Metastatic cancer	11.95%	2.50	2.44 - 2.56	< 0.001
Obesity	17.34%	1.59	1.56 - 1.62	< 0.001
Alcohol-related disorders	26.25%	0.91	0.89 - 0.93	< 0.001
Smoking	19.71%	1.47	1.45 - 1.50	< 0.001
Multiple sclerosis	25.98%	1.17	1.14 - 1.20	< 0.001
Fibromyalgia	35.94%	0.76	0.74 - 0.77	< 0.001
Depression rates among patients with IBS and different chronic conditions after excluding patients with co-diagnosis of fibromyalgia, chronic pain syndrome and anxiety
IBS	18.06%	--	--	--
Congestive heart failure	9.49%	1.49	1.45 - 1.53	< 0.001
Chronic ischemic heart disease	9.66%	1.42	1.38 - 1.45	< 0.001
Diabetes	10.51%	1.35	1.31 - 1.38	< 0.001
End-stage kidney disease on dialysis	9.18%	1.59	1.55 -1.64	< 0.001
Inflammatory bowel disease	10.72%	1.63	1.57 - 1.68	< 0.001
Osteoarthritis	12.08%	1.27	1.24 - 1.30	< 0.001
HIV	13.24%	1.07	1.01 - 1.13	0.011
Leukemia	13.29%	2.22	2.14 - 2.29	< 0.001
Lymphoma	8.17%	2.09	2.01 - 2.18	< 0.001
Metastatic cancer	8.76%	1.93	1.85 - 2.01	0.033
Obesity	10.96%	1.38	1.34 - 1.41	< 0.001
Alcohol-related disorders	17.74%	0.78	0.76 - 0.80	< 0.001
Smoking	12.39%	1.37	1.33 - 1.40	< 0.001
Multiple sclerosis	18.22%	0.93	0.90 – 0.97	0.016

^# Multivariate logistic regression after adjusting for age, gender, and race. The chronic condition is the reference.

^* Patients who had both IBS and the specific chronic disease together were excluded.

Disclosures:

Ahmad Nawaz indicated no relevant financial relationships.

Abdelkader Chaar indicated no relevant financial relationships.

Rabia Rizwan indicated no relevant financial relationships.

Shanti Patel indicated no relevant financial relationships.

Badr Al-Bawardy: AbbVie – Speakers Bureau. Bristol Myers Squibb – Advisor or Review Panel Member, Speakers Bureau. Pfizer – Advisor or Review Panel Member. Takeda – Speakers Bureau.

Ahmad Nawaz, MD¹, Abdelkader Chaar, MD¹, Rabia Rizwan, MD¹, Shanti Patel, MD¹, Badr Al-Bawardy, MD². P0523 - Prevalence of Depression Is Higher in Irritable Bowel Syndrome Compared to Chronic GI and Non-GI Disorders, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.