Skip to main content
ACG 2023 Annual Meeting Posters Main banner
Back
Rate ePoster

Sunday Poster Session

Category: IBD

P0700 - Diagnosis of Inflammatory Bowel Disease Associated Peripheral Arthritis: A Systematic Review

Sunday, October 22, 2023
3:30 PM – 7:00 PM PT
Location: Exhibit Hall
Has Audio
Katherine Falloon, MD1, Zahra Dossaji, DO2, Pooja Mude, DO3, Jaideep Bhalla, MD4, Suha Abushamma, MD1, Ashwin Ananthakrishnan, MD, MPH5, Edward Barnes, MD, MPH, FACG6, Abhik Bhattacharya, MD7, Ben Cohen, MD, MAS1, Jean-Frederic Colombel, MD7, Raymond K.. Cross, MD, MS, FACG8, Christina Ha, MD9, Hans Herfarth, MD, PhD6, Sara Horst, MD, MPH10, Jason Hou, MD, MS, FACG11, M. Elaine Husni, MD12, Theresa M.. Kline, MLIS12, Edward V.. Loftus, MD13, Millie D. Long, MD, MPH14, Taha Qazi, MD15, David T. Rubin, MD16, Samir A. Shah, MD17, Bernadette C.. Siaton, MD, MEdHP18, Joseph Sleiman, MD19, Brian G. Feagan, MD20, Florian Rieder, MD1
1Cleveland Clinic, Cleveland, OH; 2Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV; 3Augustana Medical Center, Augustana, GA; 4CCF, Cleveland, OH; 5Massachusetts General Hospital, Boston, MA; 6University of North Carolina at Chapel Hill, Chapel Hill, NC; 7Icahn School of Medicine at Mount Sinai, New York, NY; 8University of Maryland School of Medicine, Baltimore, MD; 9Mayo Clinic Arizona, Scottsdale, AZ; 10Vanderbilt University Medical Center, Nashville, TN; 11Baylor College of Medicine, Houston, TX; 12Cleveland Clinic Foundation, Cleveland, OH; 13Mayo Clinic College of Medicine and Science, Rochester, MN; 14UNC Chapel Hill, Chapel Hill, NC; 15Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH; 16Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, IL; 17Gastroenterology Associates, Inc., Providence, RI; 18University of Maryland, Baltimore, MD; 19University of Pittsburgh Medical Center, Pittsburgh, PA; 20Western University, London, ON, Canada

Introduction: Inflammatory bowel disease (IBD) associated peripheral spondyloarthritis (pSpA) negatively affects quality of life and remains poorly understood. Consequently, evidence-based disease definitions, diagnostic strategies and treatment algorithms are lacking. This systematic review aimed to summarize current approaches to diagnosis of IBD associated pSpA to facilitate the development and validation of patient reported outcomes and imaging indices specific to this condition.

Methods: A literature search was conducted in collaboration with a medical librarian. Consensus or classification criteria, case series, cross sectional and cohort studies as well as randomized controlled trials related to diagnosis of IBD associated pSpA were included. Studies that incorporated patient data were required to meet additional inclusion criteria, including a confirmed diagnosis of IBD along with clinical or subclinical IBD associated pSpA.

Results: A total of 40 studies were eligible for analysis. Ten studies proposed or validated screening tools, classification criteria, or consensus criteria. The majority of studies incorporated patient report of symptoms along with a physical exam. Symptoms included pain, swelling, morning stiffness and limitations in performing physical activities, while physical examination most commonly comprised evaluation by a rheumatologist for swollen/tender joints or entheses. A total of 27 studies assessed the role of laboratory tests (human leukocyte antigen-B27, erythrocyte sedimentation rate, C-reactive protein) with no marker considered accurate enough to be used as a diagnostic tool. A subset of 14 studies assessed the role of imaging. The currently available data do not support imaging assessment as a robust diagnostic modality, but overall studies were insufficient to fully evaluate this issue. Due to the large heterogeneity in the available data a meta-analysis was not considered feasible.

Discussion: This systematic review indicates a lack of consistency in approaches to diagnosis of IBD associated pSpA. Until an evidence-based approach is established, the incorporation of classification criteria, Delphi consensus criteria, and physician assessment with a high index of suspicion for joint involvement in IBD should be utilized. We intend to pursue a multi-disciplinary approach to standardization of evaluation and diagnosis of IBD associated pSpA.


Disclosures:
Katherine Falloon: Janssen Pharmaceuticals – GI Fellows Steering Committee.
Zahra Dossaji indicated no relevant financial relationships.
Pooja Mude indicated no relevant financial relationships.
Jaideep Bhalla indicated no relevant financial relationships.
Suha Abushamma indicated no relevant financial relationships.
Ashwin Ananthakrishnan indicated no relevant financial relationships.
Edward Barnes: AbbVie, Inc. – Consultant. Bristol-Meyers Squibb – Consultant. Eli Lilly – Consultant. Target RWE – Consultant.
Abhik Bhattacharya indicated no relevant financial relationships.
Ben Cohen indicated no relevant financial relationships.
Jean-Frederic Colombel: AbbVie – Consultant, Grant/Research Support, lecture fees. Allergan – Consultant, Speakers Bureau. Amgen – Consultant, Speakers Bureau. AnaptysBio – Consultant. Arena Pharmaceuticals – Consultant. Boehringer Ingelheim – Consultant. Bristol Myers Squibb – Consultant, Grant/Research Support, Speakers Bureau. Celgene Corporation – Consultant. Celltrion – Consultant. Eli Lilly – Consultant. Enterome – Consultant. Ferring Pharmaceuticals – Consultant, Speakers Bureau. Galmed Research – Consultant. Genentech (Roche) – Consultant. Gilead – Consultant. Glaxo Smith Kline – Consultant. Immunic – Consultant. Imtbio – Consultant. Inotrem – Consultant. Intestinal Biotech Development – Stock Options. Invea – Consultant. Ipsen – Consultant. Iterative Scopes – Consultant. Janssen Pharmaceuticals – Consultant, Grant/Research Support. Kaleido Biosciences – Consultant. Landos – Consultant. LimmaTech Biologics AG – Consultant. Medimmune – Consultant. Merck – Consultant. Microba Life Science – Consultant. Novartis – Consultant. O Mass – Consultant. Otsuka Pharmaceutical – Consultant. Pfizer – Consultant. Prometheus – Consultant. Protagonis Therapeutics – Consultant. Sanofi – Consultant. Seres – Consultant. Shire – Consultant, Speakers Bureau. Takeda – Consultant, Grant/Research Support, lecture fees. Teva – Consultant. TiGenix – Consultant. Viela Bio – Consultant. Vifor – Consultant.
Raymond Cross: AbbVie – Consultant. Bristol Myers Squibb – Consultant. Janssen – Consultant. LabCorp – Consultant. Pfizer – Consultant. Samsung Bioepis – Consultant. Takeda – Consultant.
Christina Ha: AbbVie – Advisory Committee/Board Member, Consultant, Grant/Research Support. Bristol-Myers Squibb – Advisory Committee/Board Member, Consultant. Helmsley Charitable Trust, – Grant/Research Support. Janssen – Advisory Committee/Board Member, Consultant. Lily – Advisory Committee/Board Member, Consultant. Pfizer Inc – Advisory Committee/Board Member, Consultant, Grant/Research Support. Roivant – Advisory Committee/Board Member, Consultant. Takeda – Advisory Committee/Board Member, Consultant.
Hans Herfarth: BMS – Consultant. EXE-GI – Consultant. Fresenius Kabi – Consultant. Galapagos – Consultant. Gilead – Consultant. Janssen – Consultant. NovoNordisk – Grant/Research Support. Pfizer – Grant/Research Support. Ventyx – Consultant.
Sara Horst: Abbvie – Advisory Committee/Board Member, Consultant. Gilead – Advisory Committee/Board Member, Consultant. Janssen – Advisory Committee/Board Member, Consultant. Takeda – Advisory Committee/Board Member, Consultant. USB – Advisory Committee/Board Member, Consultant.
Jason Hou: Abbvie – Grant/Research Support. American Regent – Grant/Research Support. Celgene – Grant/Research Support. Pfizer – Grant/Research Support.
M. Elaine Husni: AbbVie – Advisory Committee/Board Member. Amgen – Advisory Committee/Board Member. Bristol Myers Squibb – Advisory Committee/Board Member. Eli Lilly – Advisory Committee/Board Member. Gilead – Advisory Committee/Board Member. Janssen – Advisory Committee/Board Member. Novartis – Advisory Committee/Board Member. Pfizer – Advisory Committee/Board Member. Regeneron – Advisory Committee/Board Member. UCB – Advisory Committee/Board Member.
Theresa Kline indicated no relevant financial relationships.
Edward Loftus: AbbVie – Consultant, Grant/Research Support. Alvotech – Consultant. Amgen – Consultant. Arena – Consultant. Avalo Therapeutics – Consultant. Boehringer Ingelheim – Consultant. Bristol Myers Squibb – Consultant, Grant/Research Support. Celgene – Consultant, Grant/Research Support. Celltrion – Consultant. Exact Sciences – Stock-publicly held company(excluding mutual/index funds). Fresenius Kabi – Consultant. Genentech – Consultant, Grant/Research Support. Gilead – Consultant, Grant/Research Support. GlaxoSmithKline – Consultant. Gossamer Bio – Consultant, Grant/Research Support. Iota Biosciences – Consultant. Iterative Scopes – Consultant. Janssen – Consultant, Grant/Research Support. KSL Diagnostics – Consultant. Lilly – Consultant. Morphic – Consultant. Ono Pharma – Consultant. Pfizer – Consultant, Grant/Research Support. Protagonist – Consultant. Receptos – Grant/Research Support. Robarts Clinical Trials – Grant/Research Support. Scipher Medicine – Consultant. Sun Pharma – Consultant. Surrozen – Consultant. Takeda – Consultant, Grant/Research Support. Theravance – Grant/Research Support. UCB – Consultant, Grant/Research Support.
Millie D. Long: AbbVie – Consultant. Bristol Myers Squibb – Consultant. Eli Lilly – Consultant, Grant/Research Support. Genentech – Consultant. Intercept – Consultant. Janssen – Consultant. Pfizer – Consultant, Grant/Research Support. Prometheus – Consultant. Roche – Consultant. Salix – Consultant. Takeda – Consultant, Grant/Research Support. Target PharmaSolutions – Consultant. UCB – Consultant. Valeant – Consultant.
Taha Qazi: Abbvie – Advisor or Review Panel Member, Speakers Bureau. BMS – Advisor or Review Panel Member, Speakers Bureau. Itierative Scope – Advisor or Review Panel Member. Janssen – Speakers Bureau.
David Rubin: AbbVie – Consultant, personal fees. AltruBio – Consultant, personal fees. Aslan Pharmaceuticals – Consultant. Athos Therapeutics – Consultant. Bellatrix Pharmaceuticals – Consultant. Boehringer Ingelheim – Consultant, personal fees. Bristol Myers Squibb – Consultant. Celgene Chronicles – Consultant. ClostraBio – Consultant. Connect BioPharma – Consultant. Corp/Syneos – Consultant. Eco R1 – Consultant. GastroIntestinal Research Foundation – Grant/Research Support. Genentech/Roche – Consultant. Gilead Sciences – Consultant, personal fees. Helmsley Charitable Trust – Grant/Research Support. Iterative Health – Consultant. Janssen Pharmaceuticals – Consultant, personal fees. Kaleido Biosciences – Consultant. Lilly – Consultant. Pfizer – Consultant, personal fees. Prometheus Biosciences – Consultant. Reistone Biopharma – Consultant, personal fees. Seres Therapeutics – Consultant. Takeda – Consultant, Grant/Research Support, Personal fees. Target RWE – Consultant. Trellus Health – Consultant.
Samir Shah indicated no relevant financial relationships.
Bernadette Siaton indicated no relevant financial relationships.
Joseph Sleiman indicated no relevant financial relationships.
Brian Feagan: AbbVie – Advisory Committee/Board Member, Consultant, Speakers Bureau. AbolerIS – Consultant. AgomAB Therapeutics – Consultant. Allianthera – Consultant. Amgen – Advisory Committee/Board Member, Consultant. AnaptysBio – Consultant. Applied Molecular Transport Inc. – Consultant. Arena Pharma – Consultant. Avir – Consultant. Azora Therapeutics – Consultant. Baxter – Consultant. BioJamp – Consultant. Biora Therapeutics – Consultant. Boehringer Ingelheim – Advisory Committee/Board Member, Consultant. Boston Pharma – Consultant. Bristol Myers Squibb – Consultant. Celgene/BMS – Advisory Committee/Board Member, Consultant. Connect BioPharma – Consultant. Cytoki – Consultant. Disc Medicine – Consultant. Duality – Consultant. EcoR1 – Advisory Committee/Board Member, Consultant. Eli Lilly – Consultant. Equillium – Consultant. Ermium – Consultant. Everest Clinical Research Corp. – Consultant. Ferring Pharmaceuticals – Consultant. First Wave – Consultant. Galapagos – Consultant. Galen Atlantica – Consultant. Genentech/Roche – Advisory Committee/Board Member, Consultant. Gilead – Consultant. GlaxoSmithKline – Advisory Committee/Board Member, Consultant. Glenmark – Consultant. Gossamer Pharma – Consultant, stock shareholder. Hoffmann-LaRoche – Consultant. Hot Spot Therapeutics – Consultant. Imhotex – Consultant. ImmunExt – Consultant. Immunic Therapeutics – Consultant. Index Pharma – Advisory Committee/Board Member, Consultant. Intact Therapeutics – Consultant. JAKAcademy – Consultant. Janssen – Advisory Committee/Board Member, Consultant, Speakers Bureau. Japan Tobacco Inc. – Consultant. Kaleido Biosciences – Consultant. L.E.K. Consulting – Consultant. Landos Biopharma – Consultant. Leadiant – Consultant. LifeSci Capital – Consultant. Lument AB – Consultant. Millennium – Consultant. MiroBio – Consultant. Morphic Therapeutics – Advisory Committee/Board Member, Consultant. Mylan – Consultant. Novartis – Advisory Committee/Board Member. OM Pharma – Consultant. Origo BioPharma – Advisory Committee/Board Member, Consultant. Orphagen – Consultant. Otsuka – Consultant. Pandion Therapeutics – Consultant. Pfizer – Advisory Committee/Board Member, Consultant. Play to Know AG – Consultant. Progenity – Advisory Committee/Board Member, Consultant. Prometheus Therapeutics and Diagnostics – Advisory Committee/Board Member, Consultant. Protagonist – Consultant. PTM Therapeutics – Consultant. Q32 Bio – Consultant. Rebiotix – Consultant. RedHill Biopharma – Consultant. Redx – Consultant. Roche – Consultant. Sandoz – Consultant. Sanofi – Consultant. Seres Therapeutics – Consultant. Silverback Therapeutics – Consultant. Surrozen Inc. – Consultant. Takeda – Advisory Committee/Board Member, Consultant, Speakers Bureau. Teva – Advisory Committee/Board Member, Consultant. Thelium – Consultant. Theravance – Consultant. Tigenix – Consultant. Tillotts Pharma – Advisory Committee/Board Member, Consultant. UCB Pharma – Consultant. VHSquared Ltd. – Consultant. Viatris – Consultant. Western University, Alimentiv Inc – Employee. Ysios – Consultant. Ysopia – Consultant. Zealand Pharma – Consultant.
Florian Rieder: 89Bio – Advisory Committee/Board Member, Consultant. Abbvie – Advisory Committee/Board Member, Consultant. Adnovate – Advisory Committee/Board Member, Consultant. Agomab – Advisory Committee/Board Member, Consultant. Allergan – Advisory Committee/Board Member, Consultant. Arena – Advisory Committee/Board Member, Consultant. Boehringer Ingelheim – Advisory Committee/Board Member, Consultant. CDISC – Advisory Committee/Board Member, Consultant. Celgene/Bristol Myers Squibb – Advisory Committee/Board Member, Consultant. Ferring – Advisory Committee/Board Member, Consultant. Galapagos – Advisory Committee/Board Member, Consultant. Galmed Pharmaceuticals – Advisory Committee/Board Member, Consultant. Genentech – Advisory Committee/Board Member, Consultant. Gilead – Advisory Committee/Board Member, Consultant. Gossamer – Advisory Committee/Board Member, Consultant. Guidepoint – Advisory Committee/Board Member, Consultant. Helmsley – Advisory Committee/Board Member, Consultant. Horizon Therapeutics – Advisory Committee/Board Member, Consultant. Image Analysis Limited – Advisory Committee/Board Member, Consultant. Index Pharmaceuticals – Advisory Committee/Board Member, Consultant. Janssen – Advisory Committee/Board Member, Consultant. Koutif Therapeutics – Advisory Committee/Board Member, Consultant. Mestag Therapeutics – Advisory Committee/Board Member, Consultant. Metacrine – Advisory Committee/Board Member, Consultant. Morphic Therapeutic – Advisory Committee/Board Member, Consultant. Organovo – Advisory Committee/Board Member, Consultant. Origo – Advisory Committee/Board Member, Consultant. Pfizer – Advisory Committee/Board Member, Consultant. Pliant – Advisory Committee/Board Member, Consultant. Prometheus Biosciences – Advisory Committee/Board Member, Consultant. Receptos – Advisory Committee/Board Member, Consultant. REDX – Advisory Committee/Board Member, Consultant. Roche – Advisory Committee/Board Member, Consultant. Samsung – Advisory Committee/Board Member, Consultant. Surmodics – Advisory Committee/Board Member, Consultant. Surrozen – Advisory Committee/Board Member, Consultant. Takeda – Advisory Committee/Board Member, Consultant. TD Cowen – Advisory Committee/Board Member, Consultant. Techlab – Advisory Committee/Board Member, Consultant. Theravance – Advisory Committee/Board Member, Consultant. Thetis Pharmaceuticals – Advisory Committee/Board Member, Consultant. UCB – Advisory Committee/Board Member, Consultant. Ysios Capital – Advisory Committee/Board Member, Consultant.


Katherine Falloon, MD1, Zahra Dossaji, DO2, Pooja Mude, DO3, Jaideep Bhalla, MD4, Suha Abushamma, MD1, Ashwin Ananthakrishnan, MD, MPH5, Edward Barnes, MD, MPH, FACG6, Abhik Bhattacharya, MD7, Ben Cohen, MD, MAS1, Jean-Frederic Colombel, MD7, Raymond K.. Cross, MD, MS, FACG8, Christina Ha, MD9, Hans Herfarth, MD, PhD6, Sara Horst, MD, MPH10, Jason Hou, MD, MS, FACG11, M. Elaine Husni, MD12, Theresa M.. Kline, MLIS12, Edward V.. Loftus, MD13, Millie D. Long, MD, MPH14, Taha Qazi, MD15, David T. Rubin, MD16, Samir A. Shah, MD17, Bernadette C.. Siaton, MD, MEdHP18, Joseph Sleiman, MD19, Brian G. Feagan, MD20, Florian Rieder, MD1. P0700 - Diagnosis of Inflammatory Bowel Disease Associated Peripheral Arthritis: A Systematic Review, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.