P2366 - Hepatocellular Carcinoma Incidence is Increasing in Older Men: A Population-Based Time-Trend Analysis Using the Global Burden of Diseases Database, 2000-2019

Award: Presidential Poster Award

Saqr Alsakarneh, MD¹, Fouad Jaber, MD¹, Vinay Jahagirdar, MD¹, Mohammad Aldiabat, MD², Nikki duong, MD³, Mohammad Almeqdadi, MD⁴, Adel Muhana, MD¹, Ahlam Alzghoul, MD⁵, Leen Al-Sayyed, MD⁶, John Helzberg, MD¹, Wendell Clarkston, MD^7
1University of Missouri-Kansas City, Kansas City, MO; ²New York University, New York, NY; ³Virginia Commonwealth University, Richmond, VA; ⁴Lahey Medical Center, Boston, MA; ⁵Jordan University of Science and Technology, Amman, 'Amman, Jordan; ⁶Saint Louis University, St. Louis, MO; ⁷University of Missouri-Kansas City School of Medicine, Saint Luke’s Hospital of Kansas City, Kansas City, MO

Introduction: Hepatocellular carcinoma (HCC) is an important cause of mortality in the United States (US), with a 5-year survival rate of 21%. Previous data indicated an increasing incidence of HCC. However, there are limited data on recent age and sex-specific incidence rates. This study aimed to conduct a time-trend analysis of HCC incidence rates using the Global Burden of Diseases (GBD) 2019 study database.

Methods: Incidence data was obtained from the GBD 2019 database, which covers ~100% of the US population. Age-adjusted incidence rates were calculated using SEER*Stat software (v.8.4.0.1, NCI) and were stratified by gender into males and females. Age-specific trends were assessed in two age sub-groups: younger adults aged ≤55 years and older adults aged >55 years. HCC was stratified by etiology of disease: HCC due to Hepatitis C (HCC-HC), Hepatitis B (HCC-HB), NASH (HCC-NASH), and alcohol (HCC-A). Time-trends, reported as annual percentage change (APC) and average APC (AAPC), were estimated using Joinpoint Regression Software (v.4.9.0.1, NCI) utilizing Monte Carlo permutation analysis.

Results: A total of 392,095 patients were diagnosed with HCC in the US between 2000-2019. Incidence rates have been increasing at different rates for all types of HCC; all-causes of liver cancer (AAPC=3.61, P< 0.1), HCC-HC (AAPC=3.71, P< 0.01), HCC-A (3.69, P< 0.01), HCC-NASH (3.67, P< 0.1), and HCC-HB (2.86, P< 0.1).

HCC incidence rates have been increasing in older adults but not younger adults (AAPC= 2.61 vs. 0.30, AAPC difference= 2.30, P< 0.001). Age-specific trends were neither identical nor parallel (P< 0.001), suggesting that HCC incidence rates are different and increasing in older adults at a greater rate than in younger adults. Similar results were observed in men (273,464 patients), with an absolute AAPC difference between older and younger adult men of 3.04 (P< 0.001). However, in women (118,631 patients), there was no significant AAPC difference between younger and older adult women (0.06, P=0.80), suggesting that the greatest disparity between HCC incidence trends between age-specific groups arises from men.

Discussion: Our results showed a significant increase in incidence rates of HCC due to hepatitis C, alcohol, and NASH. Moreover, incidence rates were increasing in older adults while remaining stable in younger adults over the last two decades. Future studies are warranted to investigate the reasons behind the increasing incidence of HCC cancer in older adults, particularly in older men.



Disclosures:


Saqr Alsakarneh, MD¹, Fouad Jaber, MD¹, Vinay Jahagirdar, MD¹, Mohammad Aldiabat, MD², Nikki duong, MD³, Mohammad Almeqdadi, MD⁴, Adel Muhana, MD¹, Ahlam Alzghoul, MD⁵, Leen Al-Sayyed, MD⁶, John Helzberg, MD¹, Wendell Clarkston, MD⁷. P2366 - Hepatocellular Carcinoma Incidence is Increasing in Older Men: A Population-Based Time-Trend Analysis Using the Global Burden of Diseases Database, 2000-2019, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.