P2381 - Impact of Self-Reported Ancestry in Hepatocellular Carcinoma in Hispanic Populations

Spencer Goble, MD¹, Cindy Narvaez-Barbecho, ², Manaswita Tappata, MD², Jhon Prieto, MD³, Domingo Balderramo, MD⁴, Enrique Carrera, MD⁵, Javier Diaz Ferrer, MD⁶, Marco Arrese, MD⁷, Andre Boonstra, PhD⁸, Jose Debes, MD, PhD^2
1Hennepin Healthcare, Minneapolis, MN; ²University of Minnesota, Minneapolis, MN; ³Centro de Enfermedades Hepaticas y Digestives, Bogota, Distrito Capital de Bogota, Colombia; ⁴Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Cordoba, Argentina; ⁵Hospital Eugenio Espejo, Quito, Pichincha, Ecuador; ⁶Universidad San Martin de Porres, Lima, Lima, Peru; ⁷Pontificia Universidad Catolica de Chile, Santiago, Pontificia Universidad Catolica de Chile, Santiago, Region Metropolitana, Chile; ⁸Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Introduction: Hepatocellular carcinoma (HCC) related to non-alcoholic fatty liver disease (NAFLD) is a growing health concern worldwide and particularly in areas of high NAFLD endemicity such as Latin America. This region has a mixed population with a diverse heritage that is rarely accounted for when looking at epidemiological studies. We assessed the differences in the epidemiology and outcomes of HCC in Latin Americans based on self-reported ancestry.

Methods: We retrospectively evaluated data from the ESCALON network, which prospectively follows patients at risk of and with HCC in six countries in South America. Self-reported ancestry data was categorized as European, Amerindian, African, Asian, Indigenous, or other. For this study we divided ancestry in two categories: European and non-European. Individuals in each category were evaluated using comparative statistics for demographics, underlying liver disease, tumor characteristics and treatment. IRB approval was obtained from all participating institutions.

Results: A total of 429 individuals with HCC from 6 countries in Latin America were studied, Argentina (34% n=145), Chile (15% n=66), Ecuador (15% n=63), Peru (15% n=66), Colombia (14% n=60), and Brazil (7% n=29). The median age was 68 years and 65% were male. 131 patients (30.5%) reported a European ancestry and 298 (69.5%) non-European ancestry. In those of European ancestry median age was 66 years and 72% were male. In the non-European ancestry cohort median age was 67 years and 62% were male. The most common causes of underlying liver disease were hepatitis C virus (38%) followed by alcohol use disorder (25%) in European ancestry and NAFLD (52%) followed by alcohol use disorder in non-European ancestry (23%). Both groups, European and non-European ancestry, had similar proportion of HCC diagnosed under surveillance (40% and 41% respectively) and similar presence of extrahepatic disease (47% and 50% respectively). 26% of those with European ancestry received curative therapy compared to 33% of those with non-European ancestry.

Discussion: This is the first study addressing ancestry in Latin Americans with HCC. We found that HCC related to NAFLD was more common in patients of non-European descent. Future studies are warranted to better understand the impact of genetics within specific regions of the continent to understand risk of HCC.


Disclosures:


Spencer Goble, MD¹, Cindy Narvaez-Barbecho, ², Manaswita Tappata, MD², Jhon Prieto, MD³, Domingo Balderramo, MD⁴, Enrique Carrera, MD⁵, Javier Diaz Ferrer, MD⁶, Marco Arrese, MD⁷, Andre Boonstra, PhD⁸, Jose Debes, MD, PhD². P2381 - Impact of Self-Reported Ancestry in Hepatocellular Carcinoma in Hispanic Populations, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.