P2620 - Weight Loss Outcomes of Endoscopic Sleeve Gastroplasty Across Age Groups

Khushboo Gala, MBBS¹, Vitor Brunaldi, MD, PhD¹, Christopher McGowan, MD², Daniel Maselli, MD³, Reem Sharaiha, MD⁴, Eric J. Vargas, MD, MS¹, Andres Acosta, MD, PhD¹, Erik Wilson, MD⁵, Brandon VanderWel, MD⁶, Michael Ujiki, MD⁷, Prashant Kedia, MD⁸, Andrew Storm, MD¹, Barham Abu Dayyeh, MD, MPH^1
1Mayo Clinic, Rochester, MN; ²True You Weight Loss, Cary, NC; ³True You Weight Loss, Atlanta, GA; ⁴New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY; ⁵University of Texas at Houston, Houston, TX; ⁶Eviva Health, Shoreline, WA; ⁷NorthShore University Health System, Evanston, IL; ⁸Methodist Dallas Medical Center, Dallas, TX

Introduction: The prevalence of obesity across age groups continues to rise. Currently, 39.8% of adults aged 20 to 39 years, 44.3% of adults aged 40 to 59 years, and 41.5% of adults aged 60 and older are obese. Endoscopic sleeve gastroplasty (ESG) has been shown to be a safe and effective therapy for the management of obesity, however, there is a paucity of literature on outcomes among different ages in the US. We aim to evaluate weight loss outcomes of ESG across adults, according to age group.

Methods: We performed a retrospective analysis of adult patients who underwent ESG from different sites from January 2013 through August 2022. Patients were categorized as young adults (YA), 18-25 years; adults (A), 26-64 years; and older adults (OA), 65 years and older (as defined by the CDC). Patient demographic and medical information were abstracted from the electronic medical records with weight records up to two years after ESG. Percent total body weight loss (%TBWL) at 6, 12, 18, and 24 months was calculated based on baseline weight at the procedure. All continuous data are summarized as the means and 95% confidence intervals (CI). Analyses by obesity class at each follow-up period were performed using ANOVA. A multivariate regression model was constructed to account for variables that differed at baseline.

Results: A total of 1503 patients from 7 sites were included (34 YA, 1488 A, and 58 OA). There were significant differences in baseline demographics with regard to sex distribution, race, and baseline weight (Table 1a). Procedural technique was similar in groups, with the exception of the use of APC for marking, which was significantly lower in A compared to YA and OA (28.8% vs. 44.1% and 41.4%, p = < 0.01) (Table 1b). YA achieved a higher %TBWL compared to A and OA at every time point, although this difference was not statistically significant (Figure 1). %TBWL for all groups was highest at 12 months (YA: 20.4 ± 11.6, A: 16.9 ± 7.8; OA: 16.8 ± 7.4, p = 0.18). OA had the lowest weight loss among groups at all time points, with a %TBWL of 16.8 ± 7.4 and 12.6 ± 6.8 at 12 and 24 months respectively. On multivariate regression analysis with baseline weight and sex as covariates, there was no significant association of %TBWL at any point with age group (p = 0.43, 0.28, 0.26, and 0.57 at 6, 12, 18, and 24 months respectively).

Discussion: Real-world data from a large cohort of patients of all age groups across the United States shows significant and sustained weight loss with ESG across age groups.



Disclosures:


Khushboo Gala, MBBS¹, Vitor Brunaldi, MD, PhD¹, Christopher McGowan, MD², Daniel Maselli, MD³, Reem Sharaiha, MD⁴, Eric J. Vargas, MD, MS¹, Andres Acosta, MD, PhD¹, Erik Wilson, MD⁵, Brandon VanderWel, MD⁶, Michael Ujiki, MD⁷, Prashant Kedia, MD⁸, Andrew Storm, MD¹, Barham Abu Dayyeh, MD, MPH¹. P2620 - Weight Loss Outcomes of Endoscopic Sleeve Gastroplasty Across Age Groups, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.