P2731 - Gastric Cancer Incidence Is Decreasing in Older Women: A Population-Based Time-Trend Analysis Using the Global Burden of Diseases Database

Saqr Alsakarneh, MD¹, Laith Numan, MD, MS², Fouad Jaber, MD¹, Mohammad Aldiabat, MD³, Razan Aljaras, MD⁴, Yazan Abboud, MD⁵, Rasheed Musa, MD⁶, Thaer Abdelfattah, MD, MPH⁷, Ala Abdel-Jalil, MD⁸, Ahmad Najdat Bazarbashi, MD^9
1University of Missouri-Kansas City, Kansas City, MO; ²Saint Louis University, St. Louis, MO; ³New York University, New York, NY; ⁴Indiana University School of Medicine, Indianapolis, IN; ⁵Rutgers New Jersey Medical School, Newark, NJ; ⁶East Tennessee State University, Johnson City, TN; ⁷Allegheny Health Network, Pittsburgh, PA; ⁸Cleveland Clinic Foundation, Cleveland, OH; ⁹Washington University School of Medicine in St. Louis, St. Louis, MO

Introduction: Gastric cancer accounts for 1.5% of all cancers in the United States (US) and is associated with a 35.7% five-year survival rate. Previous studies have shown decreasing overall incidence rates; however, there is limited data on recent age and sex-specific incidence rates. The aim of this study was to conduct a time-trend analysis of age and gender-specific gastric cancer incidence rates in the US using the Global Burden Diseases (GBD) 2019 database.

Methods: Data was obtained from the GBD 2019 database, an international database that covers 100% of gastric cancer diagnosed cases in the US from 1990 to 2019. Gastric cancer incidence rates were calculated using SEER*Stat software (v.8.4.0.1, “NCI”) and were stratified by gender, as reported in the database. Time-trends were estimated as annual percentage change (APC) and average APC (AAPC) using Joinpoint Regression Software (v.4.9.0.1, NCI) utilizing Monte Carlo permutation analysis. Pairwise comparison was conducted between gender-specific trends using the tests of parallelism and coincidence. Age-specific trends were also assessed in two age sub-groups: younger adults aged 15-49 years and older adults aged 50-74 years.

Results: A total of 855,997 patients were diagnosed with gastric cancer in the US between 1990-2019. Overall, incidence rates have been decreasing significantly in older adults but remained stable in younger adults (AAPC= -1.83 vs. -0.18, AAPC difference= 1.65, P< 0.001). Age-specific trends were not identical (P< 0.001) nor parallel (P< 0.001), suggesting that gastric cancer incidence rates are different and decreasing in older adults at a greater rate compared to younger adults. Similar results were seen in men (510,065 patients), with an absolute AAPC difference between older and younger adult men of 1.0 (P< 0.001). However, in women (345,931 patients), while similar results were seen, a greater AAPC difference between younger and older adult women of 2.3 (< 0.001) was noted, suggesting that the greatest disparity between gastric cancer incidence trends between age-specific groups arises from women.

Discussion: Our results suggest that gastric cancer incidence trends have been decreasing in older adults while stable in younger adults over the last three decades. The greatest difference between older and younger adults seemed to be arising from older women. Future studies are warranted to investigate the reasons behind decreasing gastric cancer in older adults, especially in older women.



Disclosures:


Saqr Alsakarneh, MD¹, Laith Numan, MD, MS², Fouad Jaber, MD¹, Mohammad Aldiabat, MD³, Razan Aljaras, MD⁴, Yazan Abboud, MD⁵, Rasheed Musa, MD⁶, Thaer Abdelfattah, MD, MPH⁷, Ala Abdel-Jalil, MD⁸, Ahmad Najdat Bazarbashi, MD⁹. P2731 - Gastric Cancer Incidence Is Decreasing in Older Women: A Population-Based Time-Trend Analysis Using the Global Burden of Diseases Database, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.