P3689 - Bariatric Surgery vs Glucagon-Like Peptide-1 Analogues for Reducing Risk of Major Cardiovascular Events: A Multi-Center Retrospective Cohort Study

Ayowumi A. Adekolu, MD¹, Ethan M.. Cohen, MD¹, Soban A.. Maan, MD², Joyce Foryoung, MD¹, Shyam A. Thakkar, MD¹, Shailendra Singh, MD^2
1West Virginia University School of Medicine, Morgantown, WV; ²West Virginia University, Morgantown, WV

Introduction: Bariatric surgery (BS) and Glucagon-like peptide-1 (GLP-1) analogues have both been shown to decrease the risk of adverse cardiovascular events. However, data comparing these two management strategies are lacking. Our aim was to study the comparative efficacy of BS and GLP-1 analogue medications in preventing adverse cardiovascular outcomes.

Methods: This was a large, population-based, retrospective cohort study using data from TriNetX platform. Adult patients, aged ≥ 18 years, with BMI ≥ 35 were included. Patients who underwent BS were matched with those on GLP-1 analogues using 1:1 propensity score matching (PSM) according to demographics and comorbidities. Patients with cardiovascular events prior to the index event and up to one year after index event were excluded. Cox proportional hazards model was used to estimate the hazard ratios (HRs).

Results: Before PSM, the BS cohort included 141,503 patients and the GLP-1 cohort included 615, 857 patients. After PSM, both cohorts included 118,828. Risk of heart failure, cardiovascular events, and cerebrovascular disease was significantly lower in the BS cohort compared to the GLP-1 cohort at multiple follow-up durations (3, 5, 7 and 10 years).

Discussion: Our findings suggest that BS may be more effective than GLP-1 analogues in preventing adverse cardiovascular events in obese patients.


Disclosures:


Ayowumi A. Adekolu, MD¹, Ethan M.. Cohen, MD¹, Soban A.. Maan, MD², Joyce Foryoung, MD¹, Shyam A. Thakkar, MD¹, Shailendra Singh, MD². P3689 - Bariatric Surgery vs Glucagon-Like Peptide-1 Analogues for Reducing Risk of Major Cardiovascular Events: A Multi-Center Retrospective Cohort Study, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.