P3827 - Prevalence and Risk Factors Associated With Non-Alcoholic Steatohepatitis in Patients With Helicobacter pylori Infection: A Population-Based Study

Somtochukwu Onwuzo, MD¹, Antoine Boustany, MD, MPH², Mounir Ibrahim, MD², Mohammad Abuassi, MD³, Eyad Z. Gharaibeh, MD⁴, Abdallah El Alayli, MD⁴, Thabet Qapaja, MD⁵, Chidera Onwuzo, MBBS⁶, Ashraf Almomani, MD⁷, Imad Asaad, MD^2
1Cleveland Clinic Foundation, Fairview Park, OH; ²Cleveland Clinic Foundation, Cleveland, OH; ³University of Central Florida College of Medicine, Gainesville, FL; ⁴Saint Louis University, St. Louis, MO; ⁵Cleveland Clinic, Cleveland, OH; ⁶General Hospital Lagos, Fairview Park, OH; ⁷Cleveland Clinic Florida, Weston, FL

Introduction: Helicobacter pylori (H. pylori) is associated with the development of gastrointestinal disorders ranging from gastritis to gastric cancer. The evidence of the association between non-alcoholic steatohepatitis (NASH) and H. pylori infection in the literature is scarce. Therefore, we aim to evaluate the risk of developing NASH in patients who have had a diagnosis of H-pylori infection independently of any confounding variables.

Methods: A validated multicenter and research platform database of more than 360 hospitals from 26 different healthcare systems across the United States from 1999 to September 2022 was utilized to construct this study. Patients aged 18 years and above were included. We excluded any patients who have had a diagnosis of pregnancy, cancer, or alcohol use disorder. The risk of developing NASH was calculated using a multivariate regression analysis to account for potential cofounders including Helicobacter pylori infection, obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and male gender. A two-sided P value < 0.05 was considered as statistically significant, and all statistical analyses were performed using R version 4.0.2 (R Foundation for Statistical Computing, Vienna, Austria, 2008).

Results: 79,476,132 individuals were screened in the database and 69,232,620 were selected in the final analysis after accounting for inclusion and exclusion criteria. The baseline characteristics of patients with NASH is seen in Table 1. Smokers (14.30%), patients with hyperlipidemia (70.35%), hypertension (73.86%), diabetes mellitus type 2 (56.46%), and obese patients (58.15%) were more common in patients with NASH compared to control. Using a multivariate regression analysis, the risk of NASH was increased in diabetics (OR: 3.55; 95% CI: 3.48-3.62), obese (OR: 5.93; 95% CI: 5.81-6.04), males (OR: 1.49; 95% CI: 1.46-1.52), individuals with hyperlipidemia (OR: 2.43; 95% CI: 2.38-2.49) and Helicobacter pylori infection (OR: 2.51; 95% CI: 2.31-2.73) (Figure 1)

Discussion: This is the largest population-based study in the United States illustrating an increased prevalence and odds of developing NASH in patients who have had a diagnosis of H. pylori infection after adjusting for common risk factors.



Disclosures:


Somtochukwu Onwuzo, MD¹, Antoine Boustany, MD, MPH², Mounir Ibrahim, MD², Mohammad Abuassi, MD³, Eyad Z. Gharaibeh, MD⁴, Abdallah El Alayli, MD⁴, Thabet Qapaja, MD⁵, Chidera Onwuzo, MBBS⁶, Ashraf Almomani, MD⁷, Imad Asaad, MD². P3827 - Prevalence and Risk Factors Associated With Non-Alcoholic Steatohepatitis in Patients With Helicobacter pylori Infection: A Population-Based Study, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.