Mohammad Darweesh, MD, Rasheed Musa, MD, Kamran Tate, MS, Chakradhar Reddy, MD East Tennessee State University, Johnson City, TN
Introduction: The mental health implications of nutritional status and malabsorption are significant. Malnutrition not only leads to physical changes but also contributes to psychological changes such as depression, anxiety, irritability, apathy, disrupted sleep patterns, and difficulties with concentration. In this study, our objective was to examine the impact of specific malabsorption disorders (including celiac disease, lactose intolerance, fructose intolerance, chronic pancreatitis, total pancreatectomy, partial pancreatectomy, inflammatory bowel disease, and patients who underwent bariatric surgeries) on mental health disorders, including anxiety and depression.
Methods: A retrospective study was conducted utilizing the Nationwide Inpatient Sample Database (NIS) for the years 2015 to 2019. Patients who had any of the malabsorption conditions were identified using ICD-10 diagnosis codes from all listed discharge diagnoses. In addition, patients with depression and anxiety were also identified using the ICD-10 diagnosis codes. Patients younger than 18 years of age, and missing information for age, gender, or race were excluded. Multivariate logistic regression analysis was performed to compare different predictors of disparities in the included population.
Results: Patients with a history of bariatric surgery were found to have the highest odds of depression, OR 2.25 (CI 2.32-2.28, P value< 0.000), While patients with chronic pancreatitis were found to have the highest odds of anxiety, OR 1.96, (CI 1.93-1.99, P value < 0.000). Other conditions were also associated with different mental health disorders at variable degrees as seen in the table 1.
Discussion: Malnutrition might play important role in the development of mental health disorders. Our study found that bariatric surgery had highest odds of depression and chronic pancreatitis had the highest odds of anxiety. Whether malabsorption and mental health are coexisting disorders only or consequences of depleted nutrients, it needs further studies.
Figure: Table 1: Odds ratios of different malabsorption conditions for depression and anxiety
Disclosures:
Mohammad Darweesh indicated no relevant financial relationships.
Rasheed Musa indicated no relevant financial relationships.
Kamran Tate indicated no relevant financial relationships.
Chakradhar Reddy indicated no relevant financial relationships.
Mohammad Darweesh, MD, Rasheed Musa, MD, Kamran Tate, MS, Chakradhar Reddy, MD. P4116 - The Effect of Malabsorption Disorders on Mental Health: A National Inpatient Sample Study, ACG 2023 Annual Scientific Meeting Abstracts. Vancouver, BC, Canada: American College of Gastroenterology.
